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PubPharm (113)
1
Empirical scaling factor for predicting human pharmacokinetic profiles of disproportionate metabolites using the Css-MRTpo method and chimeric mice with humanised livers
enthalten in:
Xenobiotica; the fate of foreign compounds in biological systems
| 2023
von
Kamimura, H.
|
Uehara, S.
|
Yoneda, N.
| +1
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2
Formation of reactive metabolites of benzbromarone in humanized-liver mice
enthalten in:
Drug metabolism and pharmacokinetics
| 2022
von
Cho, N.
|
Suemizu, H.
|
Kamimura, H.
| +4
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3
Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism
enthalten in:
Scientific reports
| 2022
von
Uehara, S.
|
Iida, Y.
|
Ida-Tanaka, M.
| +12
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4
Selection of the candidate compound at an early stage of new drug development : retrospective pharmacokinetic and metabolic evaluations of valsartan using common marmosets
enthalten in:
Xenobiotica; the fate of foreign compounds in biological systems
| 2022
von
Matsumoto, S.
|
Uehara, S.
|
Kamimura, H.
| +7
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5
An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals
enthalten in:
Drug metabolism and pharmacokinetics
| 2022
von
Uehara, S.
|
Higuchi, Y.
|
Yoneda, N.
| +10
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6
Selection of the candidate compound at an early stage of new drug development: retrospective pharmacokinetic and metabolic evaluations of valsartan using common marmosets
enthalten in:
Xenobiotica
| 2022
von
Matsumoto, S.
|
Uehara, S.
|
Kamimura, H.
| +7
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7
PREDICTION METHOD OF HUMAN PLASMA CONCENTRATION OF ORAL ADMINISTRATION MEDICINE OR METABOLITE THEREOF
enthalten in:
Europäisches Patentamt
| 2021
von
KAMIMURA HIDETAKA
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8
Human total clearance values and volumes of distribution of typical human cytochrome P450 2C9/19 substrates predicted by single-species allometric scaling using pharmacokinetic data sets from common marmosets genotyped for P450 2C19
enthalten in:
Xenobiotica; the fate of foreign compounds in biological systems
| 2021
von
Matsumoto, S.
|
Uehara, S.
|
Kamimura, H.
| +6
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9
Empirical and theoretical approaches for the prediction of human hepatic clearance using chimeric mice with humanised liver: the use of physiologically based scaling, a novel solution for potential overprediction due to coexisting mouse metabolism
enthalten in:
Xenobiotica
| 2021
von
Matsumoto, S.
|
Kamimura, H.
|
Nishiwaki, M.
| +3
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10
Human total clearance values and volumes of distribution of typical human cytochrome P450 2C9/19 substrates predicted by single-species allometric scaling using pharmacokinetic data sets from common marmosets genotyped forP450 2C19
enthalten in:
Xenobiotica
| 2021
von
Matsumoto, S.
|
Uehara, S.
|
Kamimura, H.
| +6
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Drug metabolism and disposition: the biological...
16
Biopharmaceutics & drug disposition
16
Drug metabolism and disposition
8
European journal of clinical pharmacology
8
Xenobiotica
7
Xenobiotica; the fate of foreign compounds in b...
6
Drug metabolism and pharmacokinetics
4
European journal of drug metabolism and pharmac...
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Journal of pharmaceutical and biomedical analysis
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Biomedical chromatography
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Biomedical chromatography : BMC
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Europäisches Patentamt
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Thema
56
Journal Article
12
Comparative Study
12
EC 2.4.1.17
12
Glucuronosyltransferase
10
Glucuronides
9
EC 2.4.1.-
8
Anti-Inflammatory Agents, Non-Steroidal
7
4TI98Z838E
7
EC 1.14.14.1
7
Estradiol
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Imidazoles
7
Pharmaceutical Preparations
6
Enzyme Inhibitors
6
Human
6
MIST guidance
6
Piperidines
6
Pyrimidines
6
UGT1A1 enzyme
6
UGT2B7
5
Allometry
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Erscheinungszeitraum
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