PREDICTION METHOD OF HUMAN PLASMA CONCENTRATION OF ORAL ADMINISTRATION MEDICINE OR METABOLITE THEREOF
To provide a prediction method of human plasma concentration of an oral administration medicine or its metabolite capable of accurately predicting human plasma concentration of the medicine after oral administration or its metabolite by a simple method.SOLUTION: A prediction method of human plasma concentration of an oral administration medicine acquires data of concentration transition after intravenous administration and data of medicine concentration transition after oral administration of a medicine to be tested in a non-human animal, and acquires a pharmacokinetic parameter of the medicine to be tested. A time (t) of the data of medicine concentration transition after oral administration is corrected by a ratio of a mean residence time (MRTpo) after oral administration and a mean residence time prediction value (MRTpo,pred) in human and is converted into a time (T) in human, and plasma concentration (C(t)) in the time (t) is corrected by a ratio (Css/Css,pred) of plasma concentration (Css) in a steady state and a plasma concentration prediction value (Css,pred) in the steady state in human and is converted into plasma concentration (C(T)) of the time (T) in human.SELECTED DRAWING: Figure 1.
| Medienart: |
|
|---|
Patent| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Europäisches Patentamt - (2021) vom: 22. Apr. Zur Gesamtaufnahme - year:2021 |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
KAMIMURA HIDETAKA [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Themen: |
Sonstige Themen: |
|---|
| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2021-04-22, Last update posted on www.tib.eu: 2024-02-22, Last updated: 2024-03-01 |
|---|
| Patentnummer: |
JP2021063689 |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
EPA012343978 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | EPA012343978 | ||
| 003 | DE-627 | ||
| 005 | 20240301101651.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230215s2021 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)EPA012343978 | ||
| 035 | |a (EPA)JP2021063689 | ||
| 035 | |a (EPA)75488021 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 0 | |a KAMIMURA HIDETAKA |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a PREDICTION METHOD OF HUMAN PLASMA CONCENTRATION OF ORAL ADMINISTRATION MEDICINE OR METABOLITE THEREOF |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Source: www.epo.org (no modifications made), First posted: 2021-04-22, Last update posted on www.tib.eu: 2024-02-22, Last updated: 2024-03-01 | ||
| 520 | |a To provide a prediction method of human plasma concentration of an oral administration medicine or its metabolite capable of accurately predicting human plasma concentration of the medicine after oral administration or its metabolite by a simple method.SOLUTION: A prediction method of human plasma concentration of an oral administration medicine acquires data of concentration transition after intravenous administration and data of medicine concentration transition after oral administration of a medicine to be tested in a non-human animal, and acquires a pharmacokinetic parameter of the medicine to be tested. A time (t) of the data of medicine concentration transition after oral administration is corrected by a ratio of a mean residence time (MRTpo) after oral administration and a mean residence time prediction value (MRTpo,pred) in human and is converted into a time (T) in human, and plasma concentration (C(t)) in the time (t) is corrected by a ratio (Css/Css,pred) of plasma concentration (Css) in a steady state and a plasma concentration prediction value (Css,pred) in the steady state in human and is converted into plasma concentration (C(T)) of the time (T) in human.SELECTED DRAWING: Figure 1 | ||
| 650 | 4 | |a tec | |
| 650 | 4 | |a G16H: Healthcare informatics, i.e. information and communication technology [ict] specially adapted for the handling or processing of medical or healthcare data | |
| 650 | 4 | |a G01N: Investigating or analysing materials by determining their chemical or physical properties (measuring or testing processes other than immunoassay, involving enzymes or microorganisms c12m, c12q) | |
| 650 | 4 | |a 615 | |
| 773 | 0 | 8 | |i Enthalten in |t Europäisches Patentamt |g (2021) vom: 22. Apr. |
| 773 | 1 | 8 | |g year:2021 |g day:22 |g month:04 |
| 856 | 4 | 0 | |u https://worldwide.espacenet.com/patent/search/family/75488021/publication/JP2021063689A1?q=JP2021063689 |z kostenfrei |3 Volltext |
| 912 | |a GBV_EPA | ||
| 951 | |a AR | ||
| 952 | |j 2021 |b 22 |c 04 | ||