Highly sensitive voltammetric determination of captopril on renewable amalgam film electrode
Copyright © 2021 Elsevier B.V. All rights reserved..
New highly sensitive voltammetric method for captopril (CPT) determination was developed. The main novelty of the work was the application of a renewable amalgam film electrode (Hg(Ag)FE) for this purpose. During the research instrumental parameters of the developed method were optimized and were as follows: tw = ts = 5 ms, Es = 5 mV, ΔE = 100 mV. Preconcentration potential and time were equal to 100 mV and 20 s, respectively. All measurements were conducted in electrolyte consisted of 0.1 M HClO4. Limit of detection was calculated and was equal to 1.9 nM (0.39 ng mL-1) for 20 s preconcentration time and Hg(Ag)FE surface area approximately 11.2 mm2. Linearity was achieved in the concentration range 0.05-1 μM. Repeatability of the method expressed as variation coefficient was estimated at 3.5% (0.15 μM CPT, n = 10). Applicability of the method was confirmed by analysis of tablets containing CPT and urine. Recoveries were in the range from 95 to 109% suggesting that the method might be assumed as accurate. Obtained results were also in good agreement with the producer declaration.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:237 |
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| Enthalten in: |
Talanta - 237(2022) vom: 15. Jan., Seite 122937 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Górska, Anna [VerfasserIn] |
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| Links: |
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| Themen: |
9G64RSX1XD |
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| Anmerkungen: |
Date Completed 08.11.2021 Date Revised 08.11.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.talanta.2021.122937 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM332747638 |
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| 520 | |a Copyright © 2021 Elsevier B.V. All rights reserved. | ||
| 520 | |a New highly sensitive voltammetric method for captopril (CPT) determination was developed. The main novelty of the work was the application of a renewable amalgam film electrode (Hg(Ag)FE) for this purpose. During the research instrumental parameters of the developed method were optimized and were as follows: tw = ts = 5 ms, Es = 5 mV, ΔE = 100 mV. Preconcentration potential and time were equal to 100 mV and 20 s, respectively. All measurements were conducted in electrolyte consisted of 0.1 M HClO4. Limit of detection was calculated and was equal to 1.9 nM (0.39 ng mL-1) for 20 s preconcentration time and Hg(Ag)FE surface area approximately 11.2 mm2. Linearity was achieved in the concentration range 0.05-1 μM. Repeatability of the method expressed as variation coefficient was estimated at 3.5% (0.15 μM CPT, n = 10). Applicability of the method was confirmed by analysis of tablets containing CPT and urine. Recoveries were in the range from 95 to 109% suggesting that the method might be assumed as accurate. Obtained results were also in good agreement with the producer declaration | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Captopril | |
| 650 | 4 | |a Renewable amalgam film electrode | |
| 650 | 4 | |a Voltammetry | |
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| 700 | 1 | |a Szlósarczyk, Marek |e verfasserin |4 aut | |
| 700 | 1 | |a Piech, Robert |e verfasserin |4 aut | |
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