Combination of Alcohol and EVOH as a New Embolic Agent : Midterm Tissue and Inflammatory Effects in a Swine Model
Copyright © 2020 Jean-François Hak et al..
OBJECTIVE: To evaluate the vascular occlusion and midterm tissue toxicity properties of a combination of ethylene-vinyl alcohol (EVOH) (Squid 18®) (75%) and alcohol (25%)-Alco-Squid 18-in a swine model.
MATERIALS AND METHODS: Alco-Squid 18 (75% Squid 18® mixed with 25% alcohol) (AS18) was compared to embolization with 96% alcohol alone and to embolization with Squid 18® (S18®) alone. An arteriovenous malformation (AVM) model was created in group 1 (n = 2). Each AVM model was then embolized with AS18 or S18® alone with evaluation of a ratio between the volume of embolic agent divided by the volume of the AVM (evaluated by CT). For group 2 (n = 5), each agent was tested on three different kidneys (upper pole kidney artery). Pre- and postinterventional CTs, angiographies, blood alcohol content dosages, and histological studies (3 months postintervention) were performed.
RESULTS: AS18 has better distal distribution than S18® alone, both in the kidneys (mean capsule-S18® distance: 3.9 mm (±0.23) and mean capsule-AS18 distance: 2.3 mm (±0.11) (p=0.029) and in the AVM model. Histological exploration found a higher rate of tubular necrosis with AS18 compared with S18® alone and alcohol alone (3.78 ± 0.44 compared to 2.33 ± 1.22 (p = 0.012) and 1.22 ± 0.67 (p < 0 .0001)). The blood alcohol content was negligible in all cases.
CONCLUSION: AS18 can suggest a better distal sclerotic and embolic character as compared with S18® alone without systemic toxicity.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:2020 |
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| Enthalten in: |
Radiology research and practice - 2020(2020) vom: 01., Seite 8831060 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hak, Jean-François [VerfasserIn] |
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| Anmerkungen: |
Date Revised 18.04.2022 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1155/2020/8831060 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM317310089 |
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| 100 | 1 | |a Hak, Jean-François |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Combination of Alcohol and EVOH as a New Embolic Agent |b Midterm Tissue and Inflammatory Effects in a Swine Model |
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| 500 | |a Date Revised 18.04.2022 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2020 Jean-François Hak et al. | ||
| 520 | |a OBJECTIVE: To evaluate the vascular occlusion and midterm tissue toxicity properties of a combination of ethylene-vinyl alcohol (EVOH) (Squid 18®) (75%) and alcohol (25%)-Alco-Squid 18-in a swine model | ||
| 520 | |a MATERIALS AND METHODS: Alco-Squid 18 (75% Squid 18® mixed with 25% alcohol) (AS18) was compared to embolization with 96% alcohol alone and to embolization with Squid 18® (S18®) alone. An arteriovenous malformation (AVM) model was created in group 1 (n = 2). Each AVM model was then embolized with AS18 or S18® alone with evaluation of a ratio between the volume of embolic agent divided by the volume of the AVM (evaluated by CT). For group 2 (n = 5), each agent was tested on three different kidneys (upper pole kidney artery). Pre- and postinterventional CTs, angiographies, blood alcohol content dosages, and histological studies (3 months postintervention) were performed | ||
| 520 | |a RESULTS: AS18 has better distal distribution than S18® alone, both in the kidneys (mean capsule-S18® distance: 3.9 mm (±0.23) and mean capsule-AS18 distance: 2.3 mm (±0.11) (p=0.029) and in the AVM model. Histological exploration found a higher rate of tubular necrosis with AS18 compared with S18® alone and alcohol alone (3.78 ± 0.44 compared to 2.33 ± 1.22 (p = 0.012) and 1.22 ± 0.67 (p < 0 .0001)). The blood alcohol content was negligible in all cases | ||
| 520 | |a CONCLUSION: AS18 can suggest a better distal sclerotic and embolic character as compared with S18® alone without systemic toxicity | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Tradi, Farouk |e verfasserin |4 aut | |
| 700 | 1 | |a Bobot, Mickael |e verfasserin |4 aut | |
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| 700 | 1 | |a Habert, Paul |e verfasserin |4 aut | |
| 700 | 1 | |a Chopinet, Sophie |e verfasserin |4 aut | |
| 700 | 1 | |a Haffner, Aurélie |e verfasserin |4 aut | |
| 700 | 1 | |a Soulez, Gilles |e verfasserin |4 aut | |
| 700 | 1 | |a Guillet, Benjamin |e verfasserin |4 aut | |
| 700 | 1 | |a Vidal, Vincent |e verfasserin |4 aut | |
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