Antivitamins B12 -Some Inaugural Milestones
© 2020 The Authors. Published by Wiley-VCH GmbH..
The recently delineated structure- and reactivity-based concept of antivitamins B12 has begun to bear fruit by the generation, and study, of a range of such B12 -dummies, either vitamin B12 -derived, or transition metal analogues that also represent potential antivitamins B12 or specific B12 -antimetabolites. As reviewed here, this has opened up new research avenues in organometallic B12 -chemistry and bioinorganic coordination chemistry. Exploratory studies with antivitamins B12 have, furthermore, revealed some of their potential, as pharmacologically interesting compounds, for inducing B12 -deficiency in a range of organisms, from hospital resistant bacteria to laboratory mice. The derived capacity of antivitamins B12 to induce functional B12 -deficiency in mammalian cells and organs also suggest their valuable potential as growth inhibitors of cancerous human and animal cells.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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Enthalten in: |
Chemistry (Weinheim an der Bergstrasse, Germany) - 26(2020), 67 vom: 01. Dez., Seite 15438-15445 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Kräutler, Bernhard [VerfasserIn] |
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Links: |
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Themen: |
Antibiotic |
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Anmerkungen: |
Date Completed 17.02.2021 Date Revised 10.11.2023 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1002/chem.202003788 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM315278129 |
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