Association between Abdominal Obesity and Incident Colorectal Cancer : A Nationwide Cohort Study in Korea
BACKGROUND: We investigated the association of waist circumference (WC) and abdominal obesity with the incident colorectal cancer risk in Korean adults.
METHODS: This nationwide population-based cohort study was based on health insurance claims data. We analyzed data from 9,959,605 participants acquired through health check-ups of the Korean National Health Insurance Service in 2009 who were followed up until the end of 2017. We performed multivariable Cox proportional hazards regression analysis.
RESULTS: During 8.3 years of follow up, 101,197 cases (1.0%) of colorectal cancer were recorded. After adjusting for potential confounders, there was a positive association between WC and colorectal cancer risk (p for trend <0.001). Abdominal obesity was associated with an increased risk of colorectal (hazard ratio: 1.10, (95% confidence interval: 1.08-1.12)), colon (1.11, 1.09-1.13), and rectal cancer (1.08, 1.05-1.10). These associations were independent of body mass index and were more pronounced in men and elderly individuals.
CONCLUSION: We revealed that higher WC is related to colorectal cancer risk, thus suggesting that abdominal obesity may be a risk factor for colorectal cancer in this East Asian population.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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Enthalten in: |
Cancers - 12(2020), 6 vom: 26. Mai |
Sprache: |
Englisch |
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Beteiligte Personen: |
Nam, Ga Eun [VerfasserIn] |
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Links: |
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Themen: |
Abdominal obesity |
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Anmerkungen: |
Date Revised 28.09.2020 published: Electronic Citation Status PubMed-not-MEDLINE |
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doi: |
10.3390/cancers12061368 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM310471443 |
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520 | |a BACKGROUND: We investigated the association of waist circumference (WC) and abdominal obesity with the incident colorectal cancer risk in Korean adults | ||
520 | |a METHODS: This nationwide population-based cohort study was based on health insurance claims data. We analyzed data from 9,959,605 participants acquired through health check-ups of the Korean National Health Insurance Service in 2009 who were followed up until the end of 2017. We performed multivariable Cox proportional hazards regression analysis | ||
520 | |a RESULTS: During 8.3 years of follow up, 101,197 cases (1.0%) of colorectal cancer were recorded. After adjusting for potential confounders, there was a positive association between WC and colorectal cancer risk (p for trend <0.001). Abdominal obesity was associated with an increased risk of colorectal (hazard ratio: 1.10, (95% confidence interval: 1.08-1.12)), colon (1.11, 1.09-1.13), and rectal cancer (1.08, 1.05-1.10). These associations were independent of body mass index and were more pronounced in men and elderly individuals | ||
520 | |a CONCLUSION: We revealed that higher WC is related to colorectal cancer risk, thus suggesting that abdominal obesity may be a risk factor for colorectal cancer in this East Asian population | ||
650 | 4 | |a Journal Article | |
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700 | 1 | |a Kwak, Jung-Myun |e verfasserin |4 aut | |
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