Isoform-specific roles of AMPK catalytic α subunits in Alzheimer's disease
AMPK is a heterotrimeric complex that serves as a major sensor of energy status in eukaryotic cells. Accumulating evidence depicts a complex role of dysregulated AMPK signaling in Alzheimer's disease (AD). In this issue of the JCI, Zimmermann et al. report on their investigation of AD-specific differential expression of AMPKα1 and AMPKα2 isoforms of the catalytic subunit and demonstrate that genetic reduction of AMPKα1, but not AMPKα2, rescued cognitive decline in AD mouse models. These findings reveal an isoform-specific role of AMPKα in the pathogenesis of AD, which likely provides a more precise target for future therapeutic development.
| Errataetall: |
CommentOn: J Clin Invest. 2020 Jul 1;130(7):3511-3527. - PMID 32213711 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:130 |
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| Enthalten in: |
The Journal of clinical investigation - 130(2020), 7 vom: 01. Juli, Seite 3403-3405 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhao, Fanpeng [VerfasserIn] |
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| Links: |
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| Themen: |
AMP-Activated Protein Kinases |
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| Anmerkungen: |
Date Completed 27.01.2021 Date Revised 02.07.2021 published: Print CommentOn: J Clin Invest. 2020 Jul 1;130(7):3511-3527. - PMID 32213711 Citation Status MEDLINE |
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| doi: |
10.1172/JCI137908 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM310349699 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a AMPK is a heterotrimeric complex that serves as a major sensor of energy status in eukaryotic cells. Accumulating evidence depicts a complex role of dysregulated AMPK signaling in Alzheimer's disease (AD). In this issue of the JCI, Zimmermann et al. report on their investigation of AD-specific differential expression of AMPKα1 and AMPKα2 isoforms of the catalytic subunit and demonstrate that genetic reduction of AMPKα1, but not AMPKα2, rescued cognitive decline in AD mouse models. These findings reveal an isoform-specific role of AMPKα in the pathogenesis of AD, which likely provides a more precise target for future therapeutic development | ||
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