Neuropeptides in gut-brain axis and their influence on host immunity and stress
© 2020 Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology..
In recent decades, neuropeptides have been found to play a major role in communication along the gut-brain axis. Various neuropeptides are expressed in the central and peripheral nervous systems, where they facilitate the crosstalk between the nervous systems and other major body systems. In addition to being critical to communication from the brain in the nervous systems, neuropeptides actively regulate immune functions in the gut in both direct and indirect ways, allowing for communication between the immune and nervous systems. In this mini review, we discuss the role of several neuropeptides, including calcitonin gene-related peptide (CGRP), pituitary adenylate cyclase-activating polypeptide (PACAP), corticotropin-releasing hormone (CRH) and phoenixin (PNX), in the gut-brain axis and summarize their functions in immunity and stress. We choose these neuropeptides to highlight the diversity of peptide communication in the gut-brain axis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
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| Enthalten in: |
Computational and structural biotechnology journal - 18(2020) vom: 17., Seite 843-851 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wei, Pingli [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 28.09.2020 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.csbj.2020.02.018 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a © 2020 Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. | ||
| 520 | |a In recent decades, neuropeptides have been found to play a major role in communication along the gut-brain axis. Various neuropeptides are expressed in the central and peripheral nervous systems, where they facilitate the crosstalk between the nervous systems and other major body systems. In addition to being critical to communication from the brain in the nervous systems, neuropeptides actively regulate immune functions in the gut in both direct and indirect ways, allowing for communication between the immune and nervous systems. In this mini review, we discuss the role of several neuropeptides, including calcitonin gene-related peptide (CGRP), pituitary adenylate cyclase-activating polypeptide (PACAP), corticotropin-releasing hormone (CRH) and phoenixin (PNX), in the gut-brain axis and summarize their functions in immunity and stress. We choose these neuropeptides to highlight the diversity of peptide communication in the gut-brain axis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a ACTH, adrenocorticotrophic hormone | |
| 650 | 4 | |a Antimicrobial peptides | |
| 650 | 4 | |a CGRP, calcitonin gene-related peptide | |
| 650 | 4 | |a CNS, central nervous system | |
| 650 | 4 | |a CRH, corticotropin-releasing hormone | |
| 650 | 4 | |a CRLR, calcitonin receptor like receptor | |
| 650 | 4 | |a Gut-brain axis | |
| 650 | 4 | |a HPA axis, hypothalamic–pituitary–adrenal axis | |
| 650 | 4 | |a Hypothalamic–pituitary–adrenal axis | |
| 650 | 4 | |a Immunity | |
| 650 | 4 | |a LPS, lipopolysaccharides | |
| 650 | 4 | |a NPY, neuropeptide Y | |
| 650 | 4 | |a Neuropeptide | |
| 650 | 4 | |a PACAP, pituitary adenylate cyclase-activating polypeptide | |
| 650 | 4 | |a PNX, phoenixin | |
| 650 | 4 | |a RAMP1, receptor activity-modifying protein1 | |
| 650 | 4 | |a SP, substance P | |
| 650 | 4 | |a Stress | |
| 650 | 4 | |a TRPV1, transient receptor potential vanilloid receptor-1 | |
| 650 | 4 | |a VIP, vasoactive intestinal peptide | |
| 650 | 4 | |a α-MSH, α-melanocyte-stimulating hormone | |
| 700 | 1 | |a Keller, Caitlin |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Lingjun |e verfasserin |4 aut | |
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