A series of terpyridine-based zinc(ii) complexes assembled for third-order nonlinear optical responses in the near-infrared region and recognizing lipid membranes
Two-photon (TP) microscopy has advantages for biological imaging in that it allows deeper tissue-penetration and excellent resolution compared with one-photon (OP) microscopy. Herein, two-photon activated nonlinear optical (NLO) materials, a terpyridine derivative ligand with a donor-acceptor (D-A) model and its corresponding four zinc(ii) complexes (Z1-Z4), were assembled and fully characterized. Based on their systematic photophysical investigations, it was found that the third-order NLO response in the near-infrared (NIR) region was significantly enhanced for the symmetrical complex Z4 compared with the other asymmetric complexes (Z1-Z3). To further explore its utility in biological systems, Z4 was selected as a two-photon probe for cellular lipid membranes, which was confirmed both by two-photon confocal microscopy and transmission electron microscopy (TEM). Furthermore, it was found that the fluorescence intensity was enhanced for complex Z4 with the addition of bioactive liposomes (1 μg mL-1). Its recognition mechanism was demonstrated by experimental methods, as well as molecular modeling calculations. These findings should open a new pathway for functional metal complexes as lipid membrane targeting probes.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2017 |
|---|---|
| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
|---|---|
| Enthalten in: |
Journal of materials chemistry. B - 5(2017), 31 vom: 21. Aug., Seite 6348-6355 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Tang, Yiwen [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Revised 08.04.2020 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.1039/c7tb01063j |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM308497317 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM308497317 | ||
| 003 | DE-627 | ||
| 005 | 20231225131846.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1039/c7tb01063j |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1028.xml |
| 035 | |a (DE-627)NLM308497317 | ||
| 035 | |a (NLM)32264451 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Tang, Yiwen |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A series of terpyridine-based zinc(ii) complexes assembled for third-order nonlinear optical responses in the near-infrared region and recognizing lipid membranes |
| 264 | 1 | |c 2017 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 08.04.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Two-photon (TP) microscopy has advantages for biological imaging in that it allows deeper tissue-penetration and excellent resolution compared with one-photon (OP) microscopy. Herein, two-photon activated nonlinear optical (NLO) materials, a terpyridine derivative ligand with a donor-acceptor (D-A) model and its corresponding four zinc(ii) complexes (Z1-Z4), were assembled and fully characterized. Based on their systematic photophysical investigations, it was found that the third-order NLO response in the near-infrared (NIR) region was significantly enhanced for the symmetrical complex Z4 compared with the other asymmetric complexes (Z1-Z3). To further explore its utility in biological systems, Z4 was selected as a two-photon probe for cellular lipid membranes, which was confirmed both by two-photon confocal microscopy and transmission electron microscopy (TEM). Furthermore, it was found that the fluorescence intensity was enhanced for complex Z4 with the addition of bioactive liposomes (1 μg mL-1). Its recognition mechanism was demonstrated by experimental methods, as well as molecular modeling calculations. These findings should open a new pathway for functional metal complexes as lipid membrane targeting probes | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Kong, Ming |e verfasserin |4 aut | |
| 700 | 1 | |a Tian, Xiaohe |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jinghang |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Qingyuan |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Aidong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Qiong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Hongping |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Jieying |e verfasserin |4 aut | |
| 700 | 1 | |a Tian, Yupeng |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of materials chemistry. B |d 2013 |g 5(2017), 31 vom: 21. Aug., Seite 6348-6355 |w (DE-627)NLM225907968 |x 2050-7518 |7 nnns |
| 773 | 1 | 8 | |g volume:5 |g year:2017 |g number:31 |g day:21 |g month:08 |g pages:6348-6355 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1039/c7tb01063j |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 5 |j 2017 |e 31 |b 21 |c 08 |h 6348-6355 | ||