Placental fibronectin staining is unaffected in pregnancies complicated by late-onset intrauterine growth restriction and small for gestational age fetuses
© 2019 International Federation of Gynecology and Obstetrics..
OBJECTIVE: To investigate the placental staining pattern of fibronectin, an extracellular matrix protein essential for trophoblastic invasion, in pre-eclampsia and fetal growth restriction.
METHODS: This was a retrospective study conducted at the University of Udine, including the placentas of women with pre-eclampsia and fetal growth restriction collected between January 1, 2001, and December 31, 2010. Fibronectin was evaluated in placental tissue micro-array by immunohistochemistry, describing localization and intensity of staining.
RESULTS: The study included the placentas of 36 women with early-onset (delivery <34 weeks of gestation) pre-eclampsia; 6 with early-onset HELLP syndrome; 17 with early-onset intrauterine growth restriction (IUGR); 14 with late-onset (delivery ≥34 weeks of gestation) pre-eclampsia; 35 with late-onset IUGR; 18 with small for gestational age (SGA) fetuses (birth weight <10th percentile); and 64 controls. Fibronectin was present both at the cell surface and in the cytoplasm. Cytoplasm staining intensity resulted higher in early forms of pregnancy-related complications compared to controls, although this was statistically significant (P<0.05) only for early-onset pre-eclampsia (P=0.085 for HELLP syndrome; P=0.091 for IUGR). Also, late-onset forms of pre-eclampsia had stronger cytoplasmic and pericellular staining compared to controls (P<0.05). Interestingly, staining of both late-onset IUGR and SGA was comparable to controls.
CONCLUSION: Fibronectin appeared to be unaffected in women with late-onset IUGR and SGA fetuses, suggesting a peculiar common pathogenetic pattern in these conditions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:148 |
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| Enthalten in: |
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics - 148(2020), 2 vom: 01. Feb., Seite 253-260 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Fruscalzo, Arrigo [VerfasserIn] |
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| Links: |
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| Themen: |
Extracellular matrix |
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| Anmerkungen: |
Date Completed 23.03.2020 Date Revised 23.03.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/ijgo.13060 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM303464313 |
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| 100 | 1 | |a Fruscalzo, Arrigo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Placental fibronectin staining is unaffected in pregnancies complicated by late-onset intrauterine growth restriction and small for gestational age fetuses |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Completed 23.03.2020 | ||
| 500 | |a Date Revised 23.03.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2019 International Federation of Gynecology and Obstetrics. | ||
| 520 | |a OBJECTIVE: To investigate the placental staining pattern of fibronectin, an extracellular matrix protein essential for trophoblastic invasion, in pre-eclampsia and fetal growth restriction | ||
| 520 | |a METHODS: This was a retrospective study conducted at the University of Udine, including the placentas of women with pre-eclampsia and fetal growth restriction collected between January 1, 2001, and December 31, 2010. Fibronectin was evaluated in placental tissue micro-array by immunohistochemistry, describing localization and intensity of staining | ||
| 520 | |a RESULTS: The study included the placentas of 36 women with early-onset (delivery <34 weeks of gestation) pre-eclampsia; 6 with early-onset HELLP syndrome; 17 with early-onset intrauterine growth restriction (IUGR); 14 with late-onset (delivery ≥34 weeks of gestation) pre-eclampsia; 35 with late-onset IUGR; 18 with small for gestational age (SGA) fetuses (birth weight <10th percentile); and 64 controls. Fibronectin was present both at the cell surface and in the cytoplasm. Cytoplasm staining intensity resulted higher in early forms of pregnancy-related complications compared to controls, although this was statistically significant (P<0.05) only for early-onset pre-eclampsia (P=0.085 for HELLP syndrome; P=0.091 for IUGR). Also, late-onset forms of pre-eclampsia had stronger cytoplasmic and pericellular staining compared to controls (P<0.05). Interestingly, staining of both late-onset IUGR and SGA was comparable to controls | ||
| 520 | |a CONCLUSION: Fibronectin appeared to be unaffected in women with late-onset IUGR and SGA fetuses, suggesting a peculiar common pathogenetic pattern in these conditions | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Extracellular matrix | |
| 650 | 4 | |a Fetal growth retardation | |
| 650 | 4 | |a Fibronectin | |
| 650 | 4 | |a Immunohistochemistry | |
| 650 | 4 | |a Placenta | |
| 650 | 4 | |a Pre-eclampsia | |
| 650 | 4 | |a Small for gestational age | |
| 650 | 7 | |a FN1 protein, human |2 NLM | |
| 650 | 7 | |a Fibronectins |2 NLM | |
| 700 | 1 | |a Londero, Ambrogio P |e verfasserin |4 aut | |
| 700 | 1 | |a Orsaria, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Marzinotto, Stefania |e verfasserin |4 aut | |
| 700 | 1 | |a Driul, Lorenza |e verfasserin |4 aut | |
| 700 | 1 | |a Di Loreto, Carla |e verfasserin |4 aut | |
| 700 | 1 | |a Mariuzzi, Laura |e verfasserin |4 aut | |
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