Circulating soluble LR11, a differentiation regulator for vascular cells, is increased during pregnancy and exaggerated in patients with pre-eclampsia
Copyright © 2019 Elsevier B.V. All rights reserved..
BACKGROUND: Pre-eclampsia is a pregnancy-specific disease characterized by onset of hypertension and proteinuria, sometimes progressing into damaging other organs. Here, we investigated the pathological significance of the soluble fragment of LR11 (sLR11), a cell differentiation regulator, in comparison to circulating IL-6 and TNF-α, in pre-eclampsia.
METHODS: The study was conducted in a cross-sectional research design with fourteen pre-eclampsia patients and fifty healthy pregnant subjects. Pre-eclampsia was defined as hypertensive disorders in pregnancy at over 20 weeks of gestation with proteinuria.
RESULTS: Plasma levels of sLR11 as well as IL-6 in pre-eclampsia were increased compared with those in the healthy pregnant subjects at the first, the second, and the third trimester. Receiver operating characteristic analysis for the detection of pre-eclampsia among third-trimester subjects showed that the areas under the curves of sLR11 and IL-6 were equivalent. sLR11 and IL-6 correlated positively with TNF-α in healthy pregnant subjects. In the pre-eclampsia patients, there was neither a correlation between sLR11 and IL-6 nor between sLR11 and TNF-α.
CONCLUSIONS: sLR11 increases during pregnancy, with levels further exaggerated in pre-eclampsia, and may be related to the pathology of pre-eclampsia.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2019 |
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Erschienen: |
2019 |
Enthalten in: |
Zur Gesamtaufnahme - volume:497 |
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Enthalten in: |
Clinica chimica acta; international journal of clinical chemistry - 497(2019) vom: 01. Okt., Seite 172-177 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Ishida, Hiroaki [VerfasserIn] |
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Links: |
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Themen: |
IL-6 |
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Anmerkungen: |
Date Completed 11.02.2020 Date Revised 11.02.2020 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1016/j.cca.2019.07.001 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM299122751 |
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245 | 1 | 0 | |a Circulating soluble LR11, a differentiation regulator for vascular cells, is increased during pregnancy and exaggerated in patients with pre-eclampsia |
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500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2019 Elsevier B.V. All rights reserved. | ||
520 | |a BACKGROUND: Pre-eclampsia is a pregnancy-specific disease characterized by onset of hypertension and proteinuria, sometimes progressing into damaging other organs. Here, we investigated the pathological significance of the soluble fragment of LR11 (sLR11), a cell differentiation regulator, in comparison to circulating IL-6 and TNF-α, in pre-eclampsia | ||
520 | |a METHODS: The study was conducted in a cross-sectional research design with fourteen pre-eclampsia patients and fifty healthy pregnant subjects. Pre-eclampsia was defined as hypertensive disorders in pregnancy at over 20 weeks of gestation with proteinuria | ||
520 | |a RESULTS: Plasma levels of sLR11 as well as IL-6 in pre-eclampsia were increased compared with those in the healthy pregnant subjects at the first, the second, and the third trimester. Receiver operating characteristic analysis for the detection of pre-eclampsia among third-trimester subjects showed that the areas under the curves of sLR11 and IL-6 were equivalent. sLR11 and IL-6 correlated positively with TNF-α in healthy pregnant subjects. In the pre-eclampsia patients, there was neither a correlation between sLR11 and IL-6 nor between sLR11 and TNF-α | ||
520 | |a CONCLUSIONS: sLR11 increases during pregnancy, with levels further exaggerated in pre-eclampsia, and may be related to the pathology of pre-eclampsia | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a IL-6 | |
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700 | 1 | |a Ebinuma, Hiroyuki |e verfasserin |4 aut | |
700 | 1 | |a Hiruta, Nobuyuki |e verfasserin |4 aut | |
700 | 1 | |a Schneider, Wolfgang J |e verfasserin |4 aut | |
700 | 1 | |a Kinoshita, Toshihiko |e verfasserin |4 aut | |
700 | 1 | |a Bujo, Hideaki |e verfasserin |4 aut | |
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