Metal-free, intermolecular carbopyridylation of alkenes via visible-light-induced reductive radical coupling
An efficient, metal-free strategy for the intermolecular three-component carbopyridylation of styrenes, enabled by Hantzsch ester and visible light, has been described. This versatile protocol gives access to important β-CF3 pyridines, through the regioselective, sequential formation of two C-C bonds without the use of exogenous catalysts. The value of this benign protocol has been demonstrated through functionalizations of natural-product- and drug-based complex molecules.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
Chemical science - 9(2018), 48 vom: 28. Dez., Seite 9012-9017 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chen, Dan [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Revised 30.09.2020 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1039/c8sc03493a |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM292758510 |
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| 245 | 1 | 0 | |a Metal-free, intermolecular carbopyridylation of alkenes via visible-light-induced reductive radical coupling |
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| 520 | |a An efficient, metal-free strategy for the intermolecular three-component carbopyridylation of styrenes, enabled by Hantzsch ester and visible light, has been described. This versatile protocol gives access to important β-CF3 pyridines, through the regioselective, sequential formation of two C-C bonds without the use of exogenous catalysts. The value of this benign protocol has been demonstrated through functionalizations of natural-product- and drug-based complex molecules | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Xu, Lei |e verfasserin |4 aut | |
| 700 | 1 | |a Long, Tianyu |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Shengqing |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Chu, Lingling |e verfasserin |4 aut | |
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