Testing the utility of mod scores and sib-pair analysis to detect presence of disease susceptibility loci
Linkage analyses and association studies were employed to detect disease susceptibility loci leading to elevated Q1 levels in Problem 2B. Phenotypes were defined to be the dichotomous affection status, the quantitative value for Q1, and Q1 adjusted for covariates. The method of mod-scores (for the dichotomous phenotype) and the Haseman-Elston sib-pair test on the dichotomous and quantitative phenotypes were used to screen for linkage of disease susceptibility genes to 367 markers. These analyses were performed on a sample ascertained from the first 60 replicates. The mod-score method detected linkage to MG1, MG2, and MG3 with scores of 1.5, 5.0, and 1.6 respectively. Sib-pair analysis using quantitative phenotypes signaled linkage only to the area surrounding MG1; the dichotomous phenotype detected linkage only to MG2. Association studies used ANOVA on all founders in the first 60 replicates and ASSOC on the ascertained families and on a subset of families from the 60 replicates but only confirmed an association to MG1. In conclusion, the mod-score method may be a useful tool for genomic screens.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
1997 |
|---|---|
| Erschienen: |
1997 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
|---|---|
| Enthalten in: |
Genetic epidemiology - 14(1997), 6 vom: 27., Seite 1035-40 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Neuman, R J [VerfasserIn] |
|---|
| Themen: |
Comparative Study |
|---|
| Anmerkungen: |
Date Completed 19.02.1998 Date Revised 14.11.2007 published: Print Citation Status MEDLINE |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
NLM093769717 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM093769717 | ||
| 003 | DE-627 | ||
| 005 | 20231222094252.0 | ||
| 007 | tu | ||
| 008 | 231222s1997 xx ||||| 00| ||eng c | ||
| 028 | 5 | 2 | |a pubmed24n0313.xml |
| 035 | |a (DE-627)NLM093769717 | ||
| 035 | |a (NLM)9433620 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Neuman, R J |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Testing the utility of mod scores and sib-pair analysis to detect presence of disease susceptibility loci |
| 264 | 1 | |c 1997 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 19.02.1998 | ||
| 500 | |a Date Revised 14.11.2007 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Linkage analyses and association studies were employed to detect disease susceptibility loci leading to elevated Q1 levels in Problem 2B. Phenotypes were defined to be the dichotomous affection status, the quantitative value for Q1, and Q1 adjusted for covariates. The method of mod-scores (for the dichotomous phenotype) and the Haseman-Elston sib-pair test on the dichotomous and quantitative phenotypes were used to screen for linkage of disease susceptibility genes to 367 markers. These analyses were performed on a sample ascertained from the first 60 replicates. The mod-score method detected linkage to MG1, MG2, and MG3 with scores of 1.5, 5.0, and 1.6 respectively. Sib-pair analysis using quantitative phenotypes signaled linkage only to the area surrounding MG1; the dichotomous phenotype detected linkage only to MG2. Association studies used ANOVA on all founders in the first 60 replicates and ASSOC on the ascertained families and on a subset of families from the 60 replicates but only confirmed an association to MG1. In conclusion, the mod-score method may be a useful tool for genomic screens | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, U.S. Gov't, P.H.S. | |
| 700 | 1 | |a Xian, H |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Genetic epidemiology |d 1984 |g 14(1997), 6 vom: 27., Seite 1035-40 |w (DE-627)NLM013343750 |x 1098-2272 |7 nnns |
| 773 | 1 | 8 | |g volume:14 |g year:1997 |g number:6 |g day:27 |g pages:1035-40 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 14 |j 1997 |e 6 |b 27 |h 1035-40 | ||