Discrepancies between diagnosed asthma, asthma-like symptoms and a test for abnormal lung function
For the diagnosis of asthma, it is neither clear to which degree various tests and symptoms identify the same subjects nor how these characteristics are best combined. We assessed the interrelationship between physician-diagnosed asthma, asthma-like symptoms and abnormal airway function in a population based sample of 495 12-15 year old schoolchildren. Participants filled in a questionnaire and underwent baseline spirometry (FEV1%), provocation with treadmill exercise (EXE) and with inhaled methacholine (PD15), and monitoring of peak expiratory flow (PEF) twice daily for two weeks. Most symptomatic subjects with any test positive were identified by PD15 alone (75%) or in combination with PEF monitoring (89%). Although interest agreement was weak (kappa < 0.40 for all pairs), significant associations were found between PD15 and EXE, between PEF and EXE and between FEV1% and PD15. However, PEF variability and methacholine responsiveness seem to identify different varieties of airway pathophysiology, and the combined use of the two tests may be helpful as an epidemiological screening tool for asthma.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1997 |
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| Erschienen: |
1997 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:159 |
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| Enthalten in: |
Ugeskrift for laeger - 159(1997), 49 vom: 01. Dez., Seite 7322-7 |
| Sprache: |
Dänisch |
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| Weiterer Titel: |
Manglende overensstemmelse mellem diagnosticeret asthma, asthmalignende symptomer og test for abnorm luftvejsfunktion |
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| Beteiligte Personen: |
Siersted, H C [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 29.12.1997 Date Revised 15.11.2006 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM093613962 |
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| 245 | 1 | 0 | |a Discrepancies between diagnosed asthma, asthma-like symptoms and a test for abnormal lung function |
| 246 | 3 | 3 | |a Manglende overensstemmelse mellem diagnosticeret asthma, asthmalignende symptomer og test for abnorm luftvejsfunktion |
| 264 | 1 | |c 1997 | |
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| 500 | |a Date Completed 29.12.1997 | ||
| 500 | |a Date Revised 15.11.2006 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a For the diagnosis of asthma, it is neither clear to which degree various tests and symptoms identify the same subjects nor how these characteristics are best combined. We assessed the interrelationship between physician-diagnosed asthma, asthma-like symptoms and abnormal airway function in a population based sample of 495 12-15 year old schoolchildren. Participants filled in a questionnaire and underwent baseline spirometry (FEV1%), provocation with treadmill exercise (EXE) and with inhaled methacholine (PD15), and monitoring of peak expiratory flow (PEF) twice daily for two weeks. Most symptomatic subjects with any test positive were identified by PD15 alone (75%) or in combination with PEF monitoring (89%). Although interest agreement was weak (kappa < 0.40 for all pairs), significant associations were found between PD15 and EXE, between PEF and EXE and between FEV1% and PD15. However, PEF variability and methacholine responsiveness seem to identify different varieties of airway pathophysiology, and the combined use of the two tests may be helpful as an epidemiological screening tool for asthma | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Jeppesen, G M |e verfasserin |4 aut | |
| 700 | 1 | |a Hyldebrandt, N |e verfasserin |4 aut | |
| 700 | 1 | |a Hansen, H S |e verfasserin |4 aut | |
| 700 | 1 | |a Boldsen, J L |e verfasserin |4 aut | |
| 700 | 1 | |a Oxhøj, H |e verfasserin |4 aut | |
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