Lipopolysaccharide-Binding Protein Serum Levels in Patients with Severe Sepsis Due to Gram-Positive and Fungal Infections
Lipopolysaccharide-binding protein (LBP) is increased in patients with severe gram-negative infections, but LBP serum levels have not been reported for in patients with gram-positive and fungal infections. LBP serum levels were determined in patients with severe sepsis secondary to gram-positive or fungal infections and were compared with LBP serum levels obtained from patients with gram-negative mixed infections and from healthy volunteers. Thirty-seven episodes of severe sepsis were analyzed among 24 patients. LBP serum levels were significantly increased in patients with severe sepsis (46.4 28.3 g/mL), compared with that of healthy volunteers (5.7 1.9 g/mL; P <.0001). On the other hand, LBP serum levels obtained from patients with gram-negative infections (40.80 34.79 g/mL) did not differ from those obtained from patients with grampositive (35.55 23.95 g/mL) or fungal (39.90 22.19 g/mL) infections. These data suggest that LBP is an aspecific marker of sepsis, and the response was not clearly correlated with severity. Furthermore, in patients with multiple episodes of sepsis, LBP response seems to be of lesser magnitude after each subsequent episode of severe sepsis..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2003 |
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| Erschienen: |
2003 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:187 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Blairon, Laurent [VerfasserIn] |
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| Links: |
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| Themen: |
Biological sciences |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
JST048987530 |
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| 245 | 1 | 0 | |a Lipopolysaccharide-Binding Protein Serum Levels in Patients with Severe Sepsis Due to Gram-Positive and Fungal Infections |
| 264 | 1 | |c 2003 | |
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| 520 | |a Lipopolysaccharide-binding protein (LBP) is increased in patients with severe gram-negative infections, but LBP serum levels have not been reported for in patients with gram-positive and fungal infections. LBP serum levels were determined in patients with severe sepsis secondary to gram-positive or fungal infections and were compared with LBP serum levels obtained from patients with gram-negative mixed infections and from healthy volunteers. Thirty-seven episodes of severe sepsis were analyzed among 24 patients. LBP serum levels were significantly increased in patients with severe sepsis (46.4 28.3 g/mL), compared with that of healthy volunteers (5.7 1.9 g/mL; P <.0001). On the other hand, LBP serum levels obtained from patients with gram-negative infections (40.80 34.79 g/mL) did not differ from those obtained from patients with grampositive (35.55 23.95 g/mL) or fungal (39.90 22.19 g/mL) infections. These data suggest that LBP is an aspecific marker of sepsis, and the response was not clearly correlated with severity. Furthermore, in patients with multiple episodes of sepsis, LBP response seems to be of lesser magnitude after each subsequent episode of severe sepsis. | ||
| 540 | |a Copyright 2003 Infectious Diseases Society of America | ||
| 650 | 4 | |a Health sciences |x Medical conditions |x Symptoms |x Pain |x Musculoskeletal pain |x Back pain |x Low back pain | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Infections |x Sepsis | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Infections | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Shock |x Septic shock | |
| 650 | 4 | |a Biological sciences |x Biology |x Microbiology |x Microorganisms | |
| 650 | 4 | |a Biological sciences |x Biology |x Mycology |x Fungi | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Infections |x Fungal infections | |
| 650 | 4 | |a Health sciences |x Medical sciences |x Immunology |x Immune system |x Immune response |x Adaptive immunity |x Active immunity |x Humoral immunity |x Antigens |x Bacterial antigens |x Bacterial polysaccharides |x Lipopolysaccharides | |
| 650 | 4 | |a Biological sciences |x Biology |x Physiology |x Body composition |x Body fluids |x Blood | |
| 650 | 4 | |a Mathematics |x Applied mathematics |x Statistics |x Applied statistics |x Descriptive statistics |x Central tendencies |x Statistical median |x Major Articles |x Pathogenesis and Host Response | |
| 655 | 4 | |a research-article | |
| 700 | 1 | |a Wittebole, Xavier |e verfasserin |4 aut | |
| 700 | 1 | |a Laterre, Pierre-François |e verfasserin |4 aut | |
| 773 | 1 | 8 | |g volume:187 |g year:2003 |g number:2 |g pages:287-291 |
| 856 | 4 | 0 | |u https://www.jstor.org/stable/30085346 |3 Volltext |
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| 952 | |d 187 |j 2003 |e 2 |h 287-291 | ||