一种新型冠状病毒亚单位纳米疫苗的制备和应用
本发明公开了一种新型冠状病毒亚单位纳米疫苗制备方法和应用，所述纳米疫苗包含SARS‑CoV‑2病毒棘突蛋白的S1亚基蛋白、单磷脂酰A、CpG寡脱氧核苷酸、阳离子脂质和辅助脂质，制备得到的纳米颗粒尺寸均匀。动物实验结果显示，纳米疫苗组比游离抗原/单磷脂酰A、CpG寡脱氧核苷酸组、游离抗原/铝佐剂组具有更强的激活体液免疫、细胞免疫的能力。本发明对于预防或治疗由SARS‑CoV‑2引起的COVID‑19具有重要的应用价值。.
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Patent| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Europäisches Patentamt - (2022) vom: 17. Mai Zur Gesamtaufnahme - year:2022 |
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| Sprache: |
Chinesisch |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2022-05-17, Last update posted on www.tib.eu: 2022-09-06, Last updated: 2023-02-09 |
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| Patentnummer: |
CN111603556 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA006536794 |
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| 520 | |a 本发明公开了一种新型冠状病毒亚单位纳米疫苗制备方法和应用，所述纳米疫苗包含SARS‑CoV‑2病毒棘突蛋白的S1亚基蛋白、单磷脂酰A、CpG寡脱氧核苷酸、阳离子脂质和辅助脂质，制备得到的纳米颗粒尺寸均匀。动物实验结果显示，纳米疫苗组比游离抗原/单磷脂酰A、CpG寡脱氧核苷酸组、游离抗原/铝佐剂组具有更强的激活体液免疫、细胞免疫的能力。本发明对于预防或治疗由SARS‑CoV‑2引起的COVID‑19具有重要的应用价值。 | ||
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