Suchergebnisse - "Wood, Michael W"

PubPharm (82)

31

Challenges in the development of an M4 PAM in vivo tool compound : The discovery of VU0467154 and unexpected DMPK profiles of close analogs

enthalten in: Bioorganic & medicinal chemistry letters | 2017

von Wood, M. | Noetzel, M. | Poslusney, M. | +17

32

Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs

enthalten in: Bioorganic & medicinal chemistry letters | 2017

von Wood, M. | Noetzel, M. | Poslusney, M. | +17

33

Optimization of M4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology

enthalten in: Bioorganic & medicinal chemistry letters | 2017

von Melancon, B. | Wood, M. | Wood, M. | +18

34

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

enthalten in: Nature | 2017

von Shi, Y. | Yamada, K. | Liddelow, S. | +30

35

Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core : Challenges in disposition

enthalten in: Bioorganic & medicinal chemistry letters | 2016

von Wood, M. | Noetzel, M. | Tarr, J. | +15

36

Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core

enthalten in: Bioorganic & medicinal chemistry letters | 2016

von Wood, M. | Noetzel, M. | Engers, J. | +22

37

Listeria monocytogenes septicemia in an immunocompromised dog

enthalten in: Veterinary clinical pathology | 2016

von Pritchard, J. | Jacob, M. | Ward, T. | +3

38

State-dependent alterations in sleep/wake architecture elicited by the M4 PAM VU0467154 - Relation to antipsychotic-like drug effects

enthalten in: Neuropharmacology | 2016

von Gould, R. | Nedelcovych, M. | Gong, X. | +15

39

Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes

enthalten in: PloS one | 2016

von Fan, J. | Zareyan, S. | Zhao, W. | +9

40

Fragment-assisted hit investigation involving integrated HTS and fragment screening : Application to the identification of phosphodiesterase 10A (PDE10A) inhibitors

enthalten in: Bioorganic & medicinal chemistry letters | 2016

von Varnes, J. | Geschwindner, S. | Holmquist, C. | +7