Suchergebnisse - "Wood, Michael W"

PubPharm (32)

1

Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs

enthalten in: Bioorganic & medicinal chemistry letters | 2017

von Wood, M. | Noetzel, M. | Poslusney, M. | +17

2

Optimization of M4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology

enthalten in: Bioorganic & medicinal chemistry letters | 2017

von Melancon, B. | Wood, M. | Wood, M. | +18

3

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

enthalten in: Nature | 2017

von Shi, Y. | Yamada, K. | Liddelow, S. | +30

4

Fragment-assisted hit investigation involving integrated HTS and fragment screening: Application to the identification of phosphodiesterase 10A (PDE10A) inhibitors

enthalten in: Bioorganic & medicinal chemistry letters | 2016

von Scott, C. | Geschwindner, S. | Forst, J. | +7

5

State-dependent alterations in sleep/wake architecture elicited by the M4 PAM VU0467154 - Relation to antipsychotic-like drug effects

enthalten in: Neuropharmacology | 2016

von Gould, R. | Nedelcovych, M. | Gong, X. | +15

6

Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core

enthalten in: Bioorganic & medicinal chemistry letters | 2016

von Wood, M. | Noetzel, M. | Engers, J. | +22

7

Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition

enthalten in: Bioorganic & medicinal chemistry letters | 2016

von Wood, M. | Noetzel, M. | Tarr, J. | +15

8

Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition

enthalten in: Bioorganic & medicinal chemistry letters | 2016

von Wood, M. | Noetzel, M. | Tarr, J. | +15

9

Quantification of the interrelationships of receptor pharmacologies within a tricyclic privileged structural scaffold through application of modified forward selection

enthalten in: Neuropharmacology | 2014

von Wood, M. | Wesolowski, S. | Widzowski, D. | +1

10

2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity

enthalten in: Bioorganic & medicinal chemistry letters | 2011

von Brown, D. | Maier, D. | Sylvester, M. | +31