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PubPharm (12)
1
Challenges and Opportunities for In Vitro-In Vivo Extrapolation of Aldehyde Oxidase-Mediated Clearance : Toward a Roadmap for Quantitative Translation
enthalten in:
Drug metabolism and disposition: the biological fate of chemicals
| 2023
von
Izat, N.
|
Bolleddula, J.
|
Abbasi, A.
| +13
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2
Metabolism and Disposition of [14C]Pevonedistat, a First-in-Class NEDD8-Activating Enzyme Inhibitor, after Intravenous Infusion to Patients with Advanced Solid Tumors
enthalten in:
Drug metabolism and disposition: the biological fate of chemicals
| 2022
von
Bolleddula, J.
|
Chen, H.
|
Cohen, L.
| +6
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3
Biotransformation Pathways and Metabolite Profiles of Oral [14C]Alisertib (MLN8237), an Investigational Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors
enthalten in:
Drug metabolism and disposition: the biological fate of chemicals
| 2020
von
Pusalkar, S.
|
Zhou, X.
|
Li, Y.
| +8
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4
Biotransformation of an alpha4beta2 nicotinic acetylcholine receptor partial agonist in sprague-dawley rats and the dispositional characterization of its N-carbamoyl glucuronide metabolite
enthalten in:
Drug metabolism and disposition: the biological fate of chemicals
| 2009
von
Shaffer, C.
|
Ryder, T.
|
Venkatakrishnan, K.
| +2
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5
Metabolism and disposition of a gamma-aminobutyric acid type A receptor partial agonist in humans
enthalten in:
Drug metabolism and disposition: the biological fate of chemicals
| 2008
von
Shaffer, C.
|
Gunduz, M.
|
Vaz, A.
| +2
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6
Central nervous system pharmacokinetics of the Mdr1 P-glycoprotein substrate CP-615,003 : intersite differences and implications for human receptor occupancy projections from cerebrospinal fluid exposures
enthalten in:
Drug metabolism and disposition: the biological fate of chemicals
| 2007
von
Venkatakrishnan, K.
|
Tseng, E.
|
Nelson, F.
| +5
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7
Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions
enthalten in:
Drug metabolism and disposition: the biological fate of chemicals
| 2007
von
Obach, R.
|
Walsky, R.
|
Venkatakrishnan, K.
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8
In vitro-in vivo extrapolation of CYP2D6 inactivation by paroxetine : prediction of nonstationary pharmacokinetics and drug interaction magnitude
enthalten in:
Drug metabolism and disposition: the biological fate of chemicals
| 2005
von
Venkatakrishnan, K.
|
Obach, R.
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9
The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system : evaluation using the MDR1A/1B knockout mouse model
enthalten in:
Drug metabolism and disposition: the biological fate of chemicals
| 2005
von
Doran, A.
|
Obach, R.
|
Smith, B.
| +37
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10
Assessment of the contributions of CYP3A4 and CYP3A5 in the metabolism of the antipsychotic agent haloperidol to its potentially neurotoxic pyridinium metabolite and effect of antidepressants on the bioactivation pathway
enthalten in:
Drug metabolism and disposition: the biological fate of chemicals
| 2003
von
Kalgutkar, A.
|
Taylor, T.
|
Venkatakrishnan, K.
| +1
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Zeitschrift: Drug metabolism and disposition: the biological fate of chemicals
Medienart
12
Aufsätze
7
Gedruckte Aufsätze
5
E-Artikel
5
E-Ressourcen
Zeitschriftentitel
Drug metabolism and disposition: the biological...
Thema
12
Journal Article
5
EC 1.14.14.1
4
Comparative Study
4
Enzyme Inhibitors
3
Cytochrome P-450 CYP3A
2
41VRH5220H
2
9EI49ZU76O
2
ATP Binding Cassette Transporter, Subfamily B
2
ATP Binding Cassette Transporter, Subfamily B, ...
2
ATP-Binding Cassette Transporters
2
Cytochrome P-450 CYP2D6
2
Cytochrome P-450 CYP2D6 Inhibitors
2
GABA-A Receptor Agonists
2
Glucuronides
2
Paroxetine
2
Pyrimidines
2
Receptors, GABA-A
2
Research Support, Non-U.S. Gov't
2
Research Support, U.S. Gov't, P.H.S.
2
multidrug resistance protein 3
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weniger ...
Erscheinungszeitraum
3
2020-
9
2000-2009
Erscheinungsjahr(e)
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Sprache
12
Englisch
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