Suchergebnisse - "Polasek, Thomas M"

PubPharm (106)

1

Virtual twins for model-informed precision dosing of clozapine in patients with treatment-resistant schizophrenia

enthalten in: CPT: pharmacometrics & systems pharmacology | 2024

von Mostafa, S. | Rafizadeh, R. | Polasek, T. | +6

2

Pharmacogenomics - a minor rather than major force in clinical medicine

enthalten in: Expert review of clinical pharmacology | 2024

von Polasek, T.

3

Beyond Population-Level Targets for Drug Concentrations : Precision Dosing Needs Individual-Level Targets that Include Superior Biomarkers of Drug Responses

enthalten in: Clinical pharmacology and therapeutics | 2024

von Polasek, T. | Peck, R.

4

First-in-human single-dose study of nizubaglustat, a dual inhibitor of ceramide glucosyltransferase and non-lysosomal glucosylceramidase : Safety, tolerability, pharmacokinetics, and pharmacodynamics of single ascending and multiple doses in healthy adults

enthalten in: Molecular genetics and metabolism | 2024

von Paquet Luzy, C. | Doppler, E. | Polasek, T. | +1

5

A phase I trial of SON-1010, a tumor-targeted, interleukin-12-linked, albumin-binding cytokine, shows favorable pharmacokinetics, pharmacodynamics, and safety in healthy volunteers

enthalten in: Frontiers in immunology | 2024

von Kenney, R. | Cini, J. | Dexter, S. | +7

6

Virtual twins for model‐informed precision dosing of clozapine in patients with treatment‐resistant schizophrenia

enthalten in: CPT: Pharmacometrics & Systems Pharmacology | 2024

von Mostafa, S. | Rafizadeh, R. | Polasek, T. | +6

7

The PRESIDE (PhaRmacogEnomicS In DEpression) Trial: a double-blind randomised controlled trial of pharmacogenomic-informed prescribing of antidepressants on depression outcomes in patients with major depressive disorder in primary care.

enthalten in: ResearchSquare.com | 2023

von Saya, S. | Chondros, P. | Abela, A. | +24

8

Drug-drug interactions that alter the exposure of glucuronidated drugs : Scope, UDP-glucuronosyltransferase (UGT) enzyme selectivity, mechanisms (inhibition and induction), and clinical significance

enthalten in: Pharmacology & therapeutics | 2023

von Miners, J. | Polasek, T. | Hulin, J. | +2

9

Improving the Efficiency of Clinical Pharmacology Studies

enthalten in: Clinical pharmacology in drug development | 2023

von Polasek, T. | Schuck, V.

CommentIn: Clin Pharmacol Drug Dev. 2023 Aug;12(8):775-778. - PMID 37378863

10

The PRESIDE (PhaRmacogEnomicS In DEpression) Trial : a double-blind randomised controlled trial of pharmacogenomic-informed prescribing of antidepressants on depression outcomes in patients with major depressive disorder in primary care

enthalten in: Trials | 2023

von Saya, S. | Chondros, P. | Abela, A. | +24

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