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PubPharm (80)
1
Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation
enthalten in:
Journal of medicinal chemistry
| 2024
von
Dorel, R.
|
Sun, D.
|
Carruthers, N.
| +21
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2
Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human
enthalten in:
Xenobiotica; the fate of foreign compounds in biological systems
| 2024
von
Salphati, L.
|
Pang, J.
|
Alicke, B.
| +7
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3
Early Stage Preclinical Formulation Strategies to Alter the Pharmacokinetic Profile of Two Small Molecule Therapeutics
enthalten in:
Pharmaceuticals (Basel, Switzerland)
| 2024
von
An, L.
|
De Bruyn, T.
|
Pang, J.
| +8
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4
A New Approach for Preparing Stable High-Concentration Peptide Nanoparticle Formulations
enthalten in:
Pharmaceuticals (Basel, Switzerland)
| 2023
von
Hu, C.
|
Zang, N.
|
Tam, Y.
| +7
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5
Absorption, Metabolism, and Excretion of Taselisib (GDC-0032), a Potent β-Sparing PI3K Inhibitor in Rats, Dogs, and Humans
enthalten in:
Drug metabolism and disposition: the biological fate of chemicals
| 2023
von
Ma, S.
|
Cho, S.
|
Sahasranaman, S.
| +8
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6
Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα
enthalten in:
Journal of medicinal chemistry
| 2022
von
Hanan, E.
|
Braun, M.
|
Heald, R.
| +32
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7
Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors
enthalten in:
Journal of medicinal chemistry
| 2022
von
Hu, D.
|
Patel, S.
|
Chen, H.
| +21
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8
Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA : From a Screening Hit to Potent Wild-Type Gram-Negative Activity
enthalten in:
Journal of medicinal chemistry
| 2022
von
Verma, V.
|
Wang, L.
|
Labadie, S.
| +24
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9
Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase
enthalten in:
Bioorganic & medicinal chemistry letters
| 2022
von
Wei, B.
|
Robarge, K.
|
Labadie, S.
| +26
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10
Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1)
enthalten in:
ACS medicinal chemistry letters
| 2022
von
Chan, B.
|
Seward, E.
|
Lainchbury, M.
| +24
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80
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Journal of medicinal chemistry
17
Bioorganic & medicinal chemistry letters
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Thema
57
Journal Article
26
Phosphoinositide-3 Kinase Inhibitors
18
Protein Kinase Inhibitors
13
Sulfonamides
11
EC 2.7.1.137
11
EC 2.7.11.1
11
Pyrimidines
10
Antineoplastic Agents
10
Enzyme Inhibitors
8
Indazoles
8
Research Support, Non-U.S. Gov't
7
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperaz...
7
TOR Serine-Threonine Kinases
7
Thiophenes
6
Class I Phosphatidylinositol 3-Kinases
5
EC 2.7.1.1
5
NAV1.7 Voltage-Gated Sodium Channel
4
1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-mor...
4
ATP Binding Cassette Transporter, Subfamily G, ...
4
ATP-Binding Cassette Transporters
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Erscheinungszeitraum
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2020-
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2010-2019
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2000-2009
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