Suchergebnisse - "Ohnishi, Shuichi"

PubPharm (11)

1

Absorption, distribution, metabolism, and excretion of radiolabeled naldemedine in healthy subjects

enthalten in: Xenobiotica; the fate of foreign compounds in biological systems | 2019

von Ohnishi, S. | Fukumura, K. | Kubota, R. | +1

2

Successful Prediction of Human Pharmacokinetics by Improving Calculation Processes of Physiologically Based Pharmacokinetic Approach

enthalten in: Journal of pharmaceutical sciences | 2019

von Mayumi, K. | Ohnishi, S. | Hasegawa, H.

3

Pharmacokinetic-Pharmacodynamic Modeling of Brain Dopamine Levels Based on Dopamine Transporter Occupancy after Administration of Methylphenidate in Rats

enthalten in: The Journal of pharmacology and experimental therapeutics | 2019

von Shimizu, R. | Horiguchi, N. | Yano, K. | +4

4

Minimal contribution of P-gp on the low brain distribution of naldemedine, a peripherally acting μ-opioid receptor antagonist

enthalten in: Drug metabolism and pharmacokinetics | 2019

von Watari, R. | Matsuda, A. | Ohnishi, S. | +1

5

Absorption, distribution, metabolism, and excretion of radiolabeled naldemedine in healthy subjects

enthalten in: Xenobiotica | 2019

von Ohnishi, S. | Fukumura, K. | Kubota, R. | +1

6

Application of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells for Studies of Prodrug Hydrolysis and Drug Absorption in the Small Intestine

enthalten in: Drug metabolism and disposition: the biological fate of chemicals | 2018

von Akazawa, T. | Yoshida, S. | Ohnishi, S. | +3

7

Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization

enthalten in: Journal of medicinal chemistry | 2018

von Nakahara, K. | Fuchino, K. | Komano, K. | +20

8

Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors : Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain

enthalten in: Journal of medicinal chemistry | 2018

von Fuchino, K. | Mitsuoka, Y. | Masui, M. | +22

9

Improved Human Pharmacokinetic Prediction of Hepatically Metabolized Drugs With Species-Specific Systemic Clearance

enthalten in: Journal of pharmaceutical sciences | 2018

von Horiuchi, K. | Ohnishi, S. | Matsuzaki, T. | +6

10

Cysteine scanning mutagenesis of transmembrane domain 10 in organic anion transporting polypeptide 1B1

enthalten in: Biochemistry | 2014

von Ohnishi, S. | Hays, A. | Hagenbuch, B.