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PubPharm (18)
1
The Novel In Vitro Method to Calculate Tissue-to-Plasma Partition Coefficient in Humans for Predicting Pharmacokinetic Profiles by Physiologically-Based Pharmacokinetic Model With High Predictability
enthalten in:
Journal of pharmaceutical sciences
| 2020
von
Mayumi, K.
|
Tachibana, M.
|
Yoshida, M.
| +3
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2
Successful Prediction of Human Pharmacokinetics After Oral Administration by Optimized Physiologically Based Pharmacokinetics Approach and Permeation Assay Using Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Cells
enthalten in:
Journal of pharmaceutical sciences
| 2020
von
Mayumi, K.
|
Akazawa, T.
|
Kanazu, T.
| +2
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3
Absorption, distribution, metabolism, and excretion of radiolabeled naldemedine in healthy subjects
enthalten in:
Xenobiotica; the fate of foreign compounds in biological systems
| 2019
von
Ohnishi, S.
|
Fukumura, K.
|
Kubota, R.
| +1
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4
Successful Prediction of Human Pharmacokinetics by Improving Calculation Processes of Physiologically Based Pharmacokinetic Approach
enthalten in:
Journal of pharmaceutical sciences
| 2019
von
Mayumi, K.
|
Ohnishi, S.
|
Hasegawa, H.
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5
Pharmacokinetic-Pharmacodynamic Modeling of Brain Dopamine Levels Based on Dopamine Transporter Occupancy after Administration of Methylphenidate in Rats
enthalten in:
The Journal of pharmacology and experimental therapeutics
| 2019
von
Shimizu, R.
|
Horiguchi, N.
|
Yano, K.
| +4
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6
Minimal contribution of P-gp on the low brain distribution of naldemedine, a peripherally acting μ-opioid receptor antagonist
enthalten in:
Drug metabolism and pharmacokinetics
| 2019
von
Watari, R.
|
Matsuda, A.
|
Ohnishi, S.
| +1
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7
Absorption, distribution, metabolism, and excretion of radiolabeled naldemedine in healthy subjects
enthalten in:
Xenobiotica
| 2019
von
Ohnishi, S.
|
Fukumura, K.
|
Kubota, R.
| +1
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8
Application of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells for Studies of Prodrug Hydrolysis and Drug Absorption in the Small Intestine
enthalten in:
Drug metabolism and disposition: the biological fate of chemicals
| 2018
von
Akazawa, T.
|
Yoshida, S.
|
Ohnishi, S.
| +3
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9
Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization
enthalten in:
Journal of medicinal chemistry
| 2018
von
Nakahara, K.
|
Fuchino, K.
|
Komano, K.
| +20
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10
Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors : Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain
enthalten in:
Journal of medicinal chemistry
| 2018
von
Fuchino, K.
|
Mitsuoka, Y.
|
Masui, M.
| +22
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Sprache: Englisch
Medienart
18
Aufsätze
15
E-Artikel
15
E-Ressourcen
3
Gedruckte Aufsätze
Zeitschriftentitel
4
Journal of pharmaceutical sciences
4
Pharmaceutical research
2
Drug metabolism and pharmacokinetics
2
Journal of medicinal chemistry
1
Biochemistry
1
Biochimica et biophysica acta
1
Drug metabolism and disposition: the biological...
1
The Journal of pharmacology and experimental th...
1
Xenobiotica
1
Xenobiotica; the fate of foreign compounds in b...
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Thema
14
Journal Article
3
ATP Binding Cassette Transporter, Subfamily B, ...
3
Carnitine
3
Pharmaceutical Preparations
3
S7UI8SM58A
3
absorption
3
pharmacokinetics
2
03KSI6WLXH
2
5S6W795CQM
2
614OI1Z5WI
2
813RE8BX41
2
95782-09-5
2
98299-38-8
2
Amyloid Precursor Protein Secretases
2
EC 3.4.-
2
Enzyme Inhibitors
2
Naldemedine
2
Naltrexone
2
Organic Cation Transport Proteins
2
Oxazines
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Erscheinungszeitraum
2
2020-
10
2010-2019
6
2000-2009
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Englisch
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