Suchergebnisse - "O'Connor, Carrie"

PubPharm (27)

1

Mitochondrial and cytosolic one-carbon metabolism is a targetable metabolic vulnerability in cisplatin-resistant ovarian cancer

enthalten in: Molecular cancer therapeutics | 2024

von Wallace-Povirk, A. | O'Connor, C. | Dekhne, A. | +13

2

Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport

enthalten in: ACS medicinal chemistry letters | 2023

von Kaku, K. | Ravindra, M. | Tong, N. | +9

3

Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria

enthalten in: Journal of medicinal chemistry | 2023

von Nayeen, M. | Katinas, J. | Magdum, T. | +9

4

Multitargeted 6-Substituted Thieno[2,3-d]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism

enthalten in: ACS pharmacology & translational science | 2023

von Tong, N. | Wong-Roushar, J. | Wallace-Povirk, A. | +12

5

Correction : Novel Pyrrolo[3,2-d]Pyrimidine Compounds Target Mitochondrial and Cytosolic One-Carbon Metabolism with Broad-spectrum Antitumor Efficacy

enthalten in: Molecular cancer therapeutics | 2023

von Dekhne, A. | Shah, K. | Ducker, G. | +22

ErratumFor: Mol Cancer Ther. 2019 Oct;18(10):1787-1799. - PMID 31289137

6

Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment

enthalten in: Scientific reports | 2022

von Wallace-Povirk, A. | Rubinsak, L. | Malysa, A. | +13

7

Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors

enthalten in: Bioorganic & medicinal chemistry | 2021

von Wallace-Povirk, A. | Tong, N. | Wong-Roushar, J. | +10

8

Folate transporter dynamics and therapy with classic and tumor-targeted antifolates

enthalten in: Scientific reports | 2021

von O'Connor, C. | Wallace-Povirk, A. | Ning, C. | +5

9

Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier

enthalten in: Bioorganic & medicinal chemistry | 2020

von Golani, L. | Islam, F. | O'Connor, C. | +4

10

Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism

enthalten in: Molecular pharmacology | 2020

von Dekhne, A. | Ning, C. | Nayeen, M. | +10