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PubPharm (10)
1
Metabolite Bioanalysis in Drug Development : Recommendations from the IQ Consortium Metabolite Bioanalysis Working Group
enthalten in:
Clinical pharmacology and therapeutics
| 2024
von
Li, W.
|
Vazvaei-Smith, F.
|
Dear, G.
| +13
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2
Metabolite Bioanalysis in Drug Development : Recommendations from the IQ Consortium Metabolite Bioanalysis Working Group
enthalten in:
Clinical Pharmacology & Therapeutics
| 2024
von
Li, W.
|
Vazvaei‐Smith, F.
|
Dear, G.
| +13
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3
An innovative phase I study in healthy subjects to determine the mass balance, elimination, metabolism, and absolute bioavailability of mitapivat
enthalten in:
Clinical and translational science
| 2023
von
Prakash, C.
|
Mangus, H.
|
Yan, Y.
| +2
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4
A phase 1 dose escalation study of the pyruvate kinase activator mitapivat (AG-348) in sickle cell disease
enthalten in:
Blood
| 2022
von
Xu, J.
|
Conrey, A.
|
Frey, I.
| +17
CommentIn: Blood. 2022 Nov 10;140(19):2005-2006. - PMID 36355466
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5
Quantitation of ivosidenib in human plasma via LC-MS/MS and its application in clinical trials
enthalten in:
Bioanalysis
| 2021
von
Yin, F.
|
Yu, S.
|
Narayanaswamy, R.
| +3
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6
Decreased activity and stability of pyruvate kinase in sickle cell disease : a novel target for mitapivat therapy
enthalten in:
Blood
| 2021
von
Rab, M.
|
Bos, J.
|
van Oirschot, B.
| +11
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7
Quantitation of ivosidenib in human plasma via LC–MS/MS and its application in clinical trials
enthalten in:
Bioanalysis
| 2021
von
Yin, F.
|
Yu, S.
|
Narayanaswamy, R.
| +3
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8
Quantitation of 2-hydroxyglutarate in human plasma via LC-MS/MS using a surrogate analyte approach
enthalten in:
Bioanalysis
| 2020
von
Yin, F.
|
Ling, Y.
|
Keller, J.
| +6
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9
A double surrogate approach for the quantitation of 2-Hydroxyglutarate - An oncometabolite in human brain tumors via LC-MS/MS
enthalten in:
Journal of pharmaceutical and biomedical analysis
| 2020
von
Yin, F.
|
Keller, J.
|
Kraus, D.
| +3
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10
"Center punch" and "whole spot" bioanalysis of apixaban in human dried blood spot samples by UHPLC-MS/MS
enthalten in:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
| 2015
von
Zheng, N.
|
Yuan, L.
|
Ji, Q.
| +6
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1
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Journal of chromatography. B, Analytical techno...
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Thema
8
Journal Article
3
2WTV10SIKH
3
EC 2.7.1.40
3
IDH inhibitor
3
LC–MS/MS
3
Pyruvate Kinase
3
human plasma
3
mitapivat
3
small molecule
3
validation
2
138-81-8
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2,3-Diphosphoglycerate
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2889-31-8
2
AML
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Clinical Trial, Phase I
2
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2
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2
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2
Research Support, Non-U.S. Gov't
2
acute myeloid leukemia
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2020-
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2010-2019
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