Suchergebnisse - "Lavecchia, Antonio"

PubPharm (14)

1

A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition

enthalten in: Journal of medicinal chemistry | 2023

von Laghezza, A. | Cerchia, C. | Genovese, M. | +15

2

Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation

enthalten in: Journal of medicinal chemistry | 2018

von Laghezza, A. | Piemontese, L. | Cerchia, C. | +9

3

New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity

enthalten in: European journal of medicinal chemistry | 2017

von Piemontese, L. | Cerchia, C. | Laghezza, A. | +11

4

Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode

enthalten in: Scientific reports | 2016

von Capelli, D. | Cerchia, C. | Montanari, R. | +6

5

On the metabolically active form of metaglidasen : improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles

enthalten in: ChemMedChem | 2015

von Laghezza, A. | Montanari, R. | Lavecchia, A. | +11

6

Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175

enthalten in: European journal of medicinal chemistry | 2015

von Piemontese, L. | Fracchiolla, G. | Carrieri, A. | +11

7

LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties

enthalten in: The Journal of biological chemistry | 2014

von Gilardi, F. | Giudici, M. | Mitro, N. | +13

8

Molecular determinants for nuclear receptors selectivity : chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors α/γ agonists

enthalten in: European journal of medicinal chemistry | 2013

von Carrieri, A. | Giudici, M. | Parente, M. | +10

9

Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors α/γ dual agonists

enthalten in: Bioorganic & medicinal chemistry | 2012

von Fracchiolla, G. | Laghezza, A. | Piemontese, L. | +9

10

New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function

enthalten in: Journal of medicinal chemistry | 2009

von Fracchiolla, G. | Laghezza, A. | Piemontese, L. | +9