Suchergebnisse - "Kazuki, Yasuhiro"

PubPharm (14)

1

Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism

enthalten in: Scientific reports | 2022

von Uehara, S. | Iida, Y. | Ida-Tanaka, M. | +12

2

Evaluation of Parent- and Metabolite-Induced Mitochondrial Toxicities Using CYP-Introduced HepG2 cells

enthalten in: Journal of pharmaceutical sciences | 2021

von Takemura, A. | Gong, S. | Sato, T. | +5

3

In vivo evaluation of intestinal human CYP3A inhibition by macrolide antibiotics in CYP3A-humanised mice

enthalten in: Xenobiotica; the fate of foreign compounds in biological systems | 2021

von Minegishi, G. | Kazuki, Y. | Nitta, S. | +3

4

Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome

enthalten in: BMC biotechnology | 2020

von Ohta, Y. | Kazuki, K. | Abe, S. | +3

5

Comparison of the hepatic metabolism of triazolam in wild-type andCyp3a-knockout mice for understanding CYP3A-mediated metabolism inCYP3A-humanised mice in vivo

enthalten in: Xenobiotica; the fate of foreign compounds in biological systems | 2019

von Minegishi, G. | Kazuki, Y. | Yamasaki, Y. | +4

6

Evaluation of 4β-Hydroxycholesterol and 25-Hydroxycholesterol as Endogenous Biomarkers of CYP3A4 : Study with CYP3A-Humanized Mice

enthalten in: The AAPS journal | 2018

von Nitta, S. | Hashimoto, M. | Kazuki, Y. | +6

7

Development of Caco-2 cells co-expressing CYP3A4 and NADPH-cytochrome P450 reductase using a human artificial chromosome for the prediction of intestinal extraction ratio of CYP3A4 substrates

enthalten in: Drug metabolism and pharmacokinetics | 2017

von Takenaka, T. | Kazuki, K. | Harada, N. | +7

8

Establishment of a novel hepatocyte model that expresses four cytochrome P450 genes stably via mammalian-derived artificial chromosome for pharmacokinetics and toxicity studies

enthalten in: PloS one | 2017

von Satoh, D. | Iwado, S. | Abe, S. | +4

9

Cyp3a deficiency enhances androgen receptor activity and cholesterol synthesis in the mouse prostate

enthalten in: The Journal of steroid biochemistry and molecular biology | 2016

von Hashimoto, M. | Kobayashi, K. | Yamazaki, M. | +4

10

Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-Chromosome or Hepatocytes by Two-Dimensional Electrophoresis/Accelerator Mass Spectrometry

enthalten in: Chemical research in toxicology | 2016

von Yamazaki, H. | Suemizu, H. | Kazuki, Y. | +7