Suchergebnisse - "Kamimura, Hidetaka"

PubPharm (113)

21

Murine Cyp3a knockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans

enthalten in: Biopharmaceutics & drug disposition | 2016

von Kakuni, M. | Kawamura, A. | Kazuki, Y. | +8

22

Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound

enthalten in: Xenobiotica | 2016

von Kamimura, H. | Ito, S.

23

Simulation of human plasma concentration–time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling

enthalten in: Xenobiotica | 2016

von Kamimura, H. | Ito, S. | Chijiwa, H. | +9

24

Development of Murine Cyp3a Knockout Chimeric Mice with Humanized Liver

enthalten in: Drug metabolism and disposition: the biological fate of chemicals | 2015

von Kato, K. | Ohbuchi, M. | Hamamura, S. | +9

25

Formation of the accumulative human metabolite and human-specific glutathione conjugate of diclofenac in TK-NOG chimeric mice with humanized livers

enthalten in: Drug metabolism and disposition: the biological fate of chemicals | 2015

von Kamimura, H. | Ito, S. | Nozawa, K. | +7

26

Time-dependent inhibitory effects of (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl-23,25-dimethoxy-13,19,21,27-tetramethyl-17-(2-oxopropyl)-11,28-dioxa-4-azatricyclo[22.3.1.0(4.9)]octacos-18-ene-2,3,10,16-tetrone (FK1706), a novel nonimmunosuppressive immunophilin ligand, on CYP3A4/5 activity in humans in vivo and in vitro

enthalten in: Drug metabolism and disposition: the biological fate of chemicals | 2010

von Minematsu, T. | Lee, J. | Zha, J. | +6

27

Time-Dependent Inhibitory Effects of (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-Dihydroxy-12-(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl-23,25-dimethoxy-13,19,21,27-tetramethyl-17-(2-oxopropyl)-11,28-dioxa-4-azatricyclo[22.3.1.04.9]octacos-18-ene-2,3,10,16-tetrone (FK1706), a Novel Nonimmunosuppressive Immunophilin Ligand, on CYP3A4/5 Activity in Humans in Vivo and in Vitro

enthalten in: Drug metabolism and disposition | 2010

von Minematsu, T. | Lee, J. | Zha, J. | +6

28

Assessment of chimeric mice with humanized liver as a tool for predicting circulating human metabolites

enthalten in: Drug metabolism and pharmacokinetics | 2010

von Kamimura, H. | Nakada, N. | Suzuki, K. | +7

29

Characterization of human organic cation transporter 1 (OCT1/SLC22A1)- and OCT2 (SLC22A2)-mediated transport of 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)- 4,9-dihydro-1H-naphtho[2,3-d]imidazolium bromide (YM155 monobromide), a novel small molecule survivin suppressant

enthalten in: Drug metabolism and disposition: the biological fate of chemicals | 2010

von Minematsu, T. | Iwai, M. | Umehara, K. | +2

30

21S,23S,24R,25S,27R)-1,14-Dihydroxy-12-(E)-2-[(1R,3R,4R)-4-hydroxy Time-Dependent Inhibitory Effects of (1R,9S,12S,13R,14S,17R,18E, tetramethyl-17-(2-oxopropyl)-11,28-dioxa-4-azatricyclo[22.3.1.04.9] -octacos-18-ene-2,3,10,16-tetrone (FK1706), a Novel Nonimmunosuppressive Immunophilin Ligand, on CYP3A4/5 Activity in Humans in Vivo and in Vitro.

enthalten in: Drug metabolism and disposition | 2010

von Minematsu, T. | Lee, J. | Zha, J. | +6