Suchergebnisse - "Kamimura, Hidetaka"

PubPharm (113)

11

Empirical and theoretical approaches for the prediction of human hepatic clearance using chimeric mice with humanised liver : the use of physiologically based scaling, a novel solution for potential overprediction due to coexisting mouse metabolism

enthalten in: Xenobiotica; the fate of foreign compounds in biological systems | 2021

von Matsumoto, S. | Kamimura, H. | Nishiwaki, M. | +3

12

Human plasma concentration-time profiles of troglitazone and troglitazone sulfate simulated by in vivo experiments with chimeric mice with humanized livers and semi-physiological pharmacokinetic modeling

enthalten in: Drug metabolism and pharmacokinetics | 2020

von Ito, S. | Kamimura, H. | Yamamoto, Y. | +4

13

Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data

enthalten in: Drug metabolism and pharmacokinetics | 2020

von Nakayama, K. | Kamimura, H. | Suemizu, H. | +8

14

A novel Css-MRTpo approach to simulate oral plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite in humans using chimeric mice with humanized livers

enthalten in: Xenobiotica; the fate of foreign compounds in biological systems | 2020

von Kamimura, H. | Uehara, S. | Suemizu, H.

15

A novel Css-MRTpo approach to simulate oral plasma concentration–time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite in humans using chimeric mice with humanized livers

enthalten in: Xenobiotica | 2020

von Kamimura, H. | Uehara, S. | Suemizu, H.

16

Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling

enthalten in: Xenobiotica; the fate of foreign compounds in biological systems | 2017

von Kamimura, H. | Ito, S. | Chijiwa, H. | +9

17

Simulation of human plasma concentration–time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling

enthalten in: Xenobiotica | 2017

von Kamimura, H. | Ito, S. | Chijiwa, H. | +9

18

Assessment of chimeric mice with humanized livers in new drug development : generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound

enthalten in: Xenobiotica; the fate of foreign compounds in biological systems | 2016

von Kamimura, H. | Ito, S.

19

Murine Cyp3a knockout chimeric mice with humanized liver : prediction of the metabolic profile of nefazodone in humans

enthalten in: Biopharmaceutics & drug disposition | 2016

von Nakada, N. | Kawamura, A. | Kamimura, H. | +8

20

Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound

enthalten in: Xenobiotica | 2016

von Kamimura, H. | Ito, S.