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PubPharm (6)
1
Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data
enthalten in:
Drug metabolism and pharmacokinetics
| 2020
von
Nakayama, K.
|
Kamimura, H.
|
Suemizu, H.
| +8
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2
A novel Css-MRTpo approach to simulate oral plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite in humans using chimeric mice with humanized livers
enthalten in:
Xenobiotica; the fate of foreign compounds in biological systems
| 2020
von
Kamimura, H.
|
Uehara, S.
|
Suemizu, H.
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3
Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling
enthalten in:
Xenobiotica; the fate of foreign compounds in biological systems
| 2017
von
Kamimura, H.
|
Ito, S.
|
Chijiwa, H.
| +9
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4
Elucidation of the effects of the CYP1A2 deficiency polymorphism in the metabolism of 4-cyclohexyl-1-ethyl-7-methylpyrido[2,3-d]pyrimidine-2-(1h)-one (YM-64227), a phosphodiesterase type 4 inhibitor, and its metabolites in dogs
enthalten in:
Drug metabolism and disposition: the biological fate of chemicals
| 2006
von
Tenmizu, D.
|
Noguchi, K.
|
Kamimura, H.
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5
The canine CYP1A2 deficiency polymorphism dramatically affects the pharmacokinetics of 4-cyclohexyl-1-ethyl-7-methylpyrido[2,3-D]-pyrimidine-2-(1H)-one (YM-64227), a phosphodiesterase type 4 inhibitor
enthalten in:
Drug metabolism and disposition: the biological fate of chemicals
| 2006
von
Tenmizu, D.
|
Noguchi, K.
|
Kamimura, H.
| +2
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6
Simultaneous determination of YM-64227, a phosphodiesterase type 4 inhibitor, and its five metabolites in dog plasma by high-performance liquid chromatography with fluorescence detection
enthalten in:
Biomedical chromatography : BMC
| 2004
von
Tenmizu, D.
|
Fukunaga, Y.
|
Noguchi, K.
| +1
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1
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Thema: Pyrimidines
Medienart
6
Aufsätze
3
E-Artikel
3
E-Ressourcen
3
Gedruckte Aufsätze
Zeitschriftentitel
2
Drug metabolism and disposition: the biological...
2
Xenobiotica; the fate of foreign compounds in b...
1
Biomedical chromatography : BMC
1
Drug metabolism and pharmacokinetics
Thema
6
Journal Article
Pyrimidines
3
3',5'-Cyclic-AMP Phosphodiesterases
3
4-cyclohexyl-1-ethyl-7-methylpyrido(2,3-d)pyrim...
3
Cyclic Nucleotide Phosphodiesterases, Type 4
3
Cyclohexanes
3
EC 3.1.4.17
2
Benzofurans
2
Chimeric mouse
2
Cytochrome P-450 CYP1A2
2
EC 1.14.14.1
2
EC 2.7.1.2
2
Glucokinase
2
MIST guidance
2
N,N-dimethyl-5-((2-methyl-6-((5-methylpyrazin-2...
2
Phosphodiesterase Inhibitors
2
disproportionate metabolite
2
humanized liver
1
144O8QL0L1
1
304NUG5GF4
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