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PubPharm (56)
1
Empirical scaling factor for predicting human pharmacokinetic profiles of disproportionate metabolites using the Css-MRTpo method and chimeric mice with humanised livers
enthalten in:
Xenobiotica; the fate of foreign compounds in biological systems
| 2023
von
Kamimura, H.
|
Uehara, S.
|
Yoneda, N.
| +1
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2
Formation of reactive metabolites of benzbromarone in humanized-liver mice
enthalten in:
Drug metabolism and pharmacokinetics
| 2022
von
Cho, N.
|
Suemizu, H.
|
Kamimura, H.
| +4
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3
Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism
enthalten in:
Scientific reports
| 2022
von
Uehara, S.
|
Iida, Y.
|
Ida-Tanaka, M.
| +12
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4
Selection of the candidate compound at an early stage of new drug development : retrospective pharmacokinetic and metabolic evaluations of valsartan using common marmosets
enthalten in:
Xenobiotica; the fate of foreign compounds in biological systems
| 2022
von
Matsumoto, S.
|
Uehara, S.
|
Kamimura, H.
| +7
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5
An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals
enthalten in:
Drug metabolism and pharmacokinetics
| 2022
von
Uehara, S.
|
Higuchi, Y.
|
Yoneda, N.
| +10
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6
Human total clearance values and volumes of distribution of typical human cytochrome P450 2C9/19 substrates predicted by single-species allometric scaling using pharmacokinetic data sets from common marmosets genotyped for P450 2C19
enthalten in:
Xenobiotica; the fate of foreign compounds in biological systems
| 2021
von
Matsumoto, S.
|
Uehara, S.
|
Kamimura, H.
| +6
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7
Empirical and theoretical approaches for the prediction of human hepatic clearance using chimeric mice with humanised liver : the use of physiologically based scaling, a novel solution for potential overprediction due to coexisting mouse metabolism
enthalten in:
Xenobiotica; the fate of foreign compounds in biological systems
| 2021
von
Matsumoto, S.
|
Kamimura, H.
|
Nishiwaki, M.
| +3
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8
Human plasma concentration-time profiles of troglitazone and troglitazone sulfate simulated by in vivo experiments with chimeric mice with humanized livers and semi-physiological pharmacokinetic modeling
enthalten in:
Drug metabolism and pharmacokinetics
| 2020
von
Ito, S.
|
Kamimura, H.
|
Yamamoto, Y.
| +4
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9
Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data
enthalten in:
Drug metabolism and pharmacokinetics
| 2020
von
Nakayama, K.
|
Kamimura, H.
|
Suemizu, H.
| +8
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10
A novel Css-MRTpo approach to simulate oral plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite in humans using chimeric mice with humanized livers
enthalten in:
Xenobiotica; the fate of foreign compounds in biological systems
| 2020
von
Kamimura, H.
|
Uehara, S.
|
Suemizu, H.
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Thema: Journal Article
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Drug metabolism and disposition: the biological...
8
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Xenobiotica; the fate of foreign compounds in b...
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Drug metabolism and pharmacokinetics
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Biomedical chromatography : BMC
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Journal Article
12
Comparative Study
12
EC 2.4.1.17
12
Glucuronosyltransferase
10
Glucuronides
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EC 2.4.1.-
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Anti-Inflammatory Agents, Non-Steroidal
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4TI98Z838E
7
EC 1.14.14.1
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Piperidines
6
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UGT1A1 enzyme
5
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5
Naphthalenes
5
Recombinant Proteins
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YM 60828
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Erscheinungszeitraum
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2020-
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2010-2019
38
2000-2009
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56
Englisch
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