Suchergebnisse - "Kamimura, Hidetaka"

PubPharm (8)

1

Selection of the candidate compound at an early stage of new drug development: retrospective pharmacokinetic and metabolic evaluations of valsartan using common marmosets

enthalten in: Xenobiotica | 2022

von Matsumoto, S. | Uehara, S. | Kamimura, H. | +7

2

Empirical and theoretical approaches for the prediction of human hepatic clearance using chimeric mice with humanised liver: the use of physiologically based scaling, a novel solution for potential overprediction due to coexisting mouse metabolism

enthalten in: Xenobiotica | 2021

von Matsumoto, S. | Kamimura, H. | Nishiwaki, M. | +3

3

Human total clearance values and volumes of distribution of typical human cytochrome P450 2C9/19 substrates predicted by single-species allometric scaling using pharmacokinetic data sets from common marmosets genotyped forP450 2C19

enthalten in: Xenobiotica | 2021

von Matsumoto, S. | Uehara, S. | Kamimura, H. | +6

4

A novel Css-MRTpo approach to simulate oral plasma concentration–time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite in humans using chimeric mice with humanized livers

enthalten in: Xenobiotica | 2020

von Kamimura, H. | Uehara, S. | Suemizu, H.

5

Simulation of human plasma concentration–time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling

enthalten in: Xenobiotica | 2017

von Kamimura, H. | Ito, S. | Chijiwa, H. | +9

6

Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound

enthalten in: Xenobiotica | 2016

von Kamimura, H. | Ito, S.

7

Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound

enthalten in: Xenobiotica | 2016

von Kamimura, H. | Ito, S.

8

Simulation of human plasma concentration–time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling

enthalten in: Xenobiotica | 2016

von Kamimura, H. | Ito, S. | Chijiwa, H. | +9

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