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topic_facet:"EC 2.7.11.1"
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/vufind/Search/Results?lookfor=%22Hu%2C+Yongzhou%22&type=Person&filter%5B%5D=topic_facet%3A%22EC+2.7.11.1%22
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PubPharm (22)
1
Discovery of seneciobipyrrolidine derivatives for the amelioration of glucose homeostasis disorders through 4E-BP1/Akt/AMPK signaling activation
enthalten in:
European journal of medicinal chemistry
| 2022
von
Che, J.
|
Ma, C.
|
Lu, J.
| +9
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2
Discovery of N-((3S,4S)-4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl-1H-pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity
enthalten in:
Journal of medicinal chemistry
| 2021
von
Che, J.
|
Dai, X.
|
Gao, J.
| +13
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3
Discovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors
enthalten in:
European journal of medicinal chemistry
| 2019
von
Zhan, W.
|
Che, J.
|
Xu, L.
| +7
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4
Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design
enthalten in:
Journal of medicinal chemistry
| 2019
von
Dong, X.
|
Zhan, W.
|
Zhao, M.
| +15
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5
Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies
enthalten in:
European journal of medicinal chemistry
| 2019
von
Tong, L.
|
Song, P.
|
Jiang, K.
| +10
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6
Phenotypic Screening-Based Identification of 3,4-Disubstituted Piperidine Derivatives as Macrophage M2 Polarization Modulators : An Opportunity for Treating Multiple Sclerosis
enthalten in:
Journal of medicinal chemistry
| 2019
von
Weng, Q.
|
Che, J.
|
Zhang, Z.
| +10
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7
Discovery of a series of N-(5-(quinolin-6-yl)pyridin-3-yl)benzenesulfonamides as PI3K/mTOR dual inhibitors
enthalten in:
European journal of medicinal chemistry
| 2017
von
Zhang, J.
|
Lv, X.
|
Ma, X.
| +1
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8
Design, synthesis and biological evaluation of pyrazol-furan carboxamide analogues as novel Akt kinase inhibitors
enthalten in:
European journal of medicinal chemistry
| 2016
von
Zhan, W.
|
Xu, L.
|
Dong, X.
| +8
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9
Discovery of novel quinoline-based mTOR inhibitors via introducing intra-molecular hydrogen bonding scaffold (iMHBS) : The design, synthesis and biological evaluation
enthalten in:
Bioorganic & medicinal chemistry
| 2015
von
Ma, X.
|
Lv, X.
|
Qiu, N.
| +3
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10
Design, synthesis and biological evaluation of novel 4-alkynyl-quinoline derivatives as PI3K/mTOR dual inhibitors
enthalten in:
European journal of medicinal chemistry
| 2015
von
Lv, X.
|
Ying, H.
|
Ma, X.
| +4
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Thema: EC 2.7.11.1
Medienart
22
Aufsätze
22
E-Artikel
22
E-Ressourcen
Zeitschriftentitel
10
European journal of medicinal chemistry
5
Bioorganic & medicinal chemistry
3
Journal of medicinal chemistry
1
Cancer letters
1
Expert opinion on drug discovery
1
Investigational new drugs
1
Journal of cancer research and clinical oncology
Alle anzeigen ...
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Thema
EC 2.7.11.1
22
Journal Article
14
Proto-Oncogene Proteins c-akt
12
Research Support, Non-U.S. Gov't
11
Protein Kinase Inhibitors
9
Antineoplastic Agents
5
TOR Serine-Threonine Kinases
3
Cancer
3
Cell Cycle Proteins
3
Enzyme Inhibitors
3
Molecular docking
3
Phosphoinositide-3 Kinase Inhibitors
3
Piperidines
3
Pyrazoles
3
Selectivity
2
Adaptor Proteins, Signal Transducing
2
Akt1 inhibitor
2
Antitumor
2
CHEK1 protein, human
2
Checkpoint Kinase 1
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Erscheinungszeitraum
2
2020-
17
2010-2019
3
2000-2009
Erscheinungsjahr(e)
Von:
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Sprache
22
Englisch
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