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journalStr:"European journal of medicinal chemistry"
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PubPharm (52)
1
Discovery of seneciobipyrrolidine derivatives for the amelioration of glucose homeostasis disorders through 4E-BP1/Akt/AMPK signaling activation
enthalten in:
European journal of medicinal chemistry
| 2022
von
Che, J.
|
Ma, C.
|
Lu, J.
| +9
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2
Identification of N-phenyl-3-methoxy-4-pyridinones as orally bioavailable H3 receptor antagonists and β-amyloid aggregation inhibitors for the treatment of Alzheimer's disease
enthalten in:
European journal of medicinal chemistry
| 2021
von
Zhang, M.
|
Tang, L.
|
Jiang, L.
| +3
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3
Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells
enthalten in:
European journal of medicinal chemistry
| 2020
von
Che, J.
|
Huang, F.
|
Zhang, M.
| +12
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4
Structurally novel PI3Kδ/γ dual inhibitors characterized by a seven-membered spirocyclic spacer : The SARs investigation and PK evaluation
enthalten in:
European journal of medicinal chemistry
| 2020
von
Tao, Q.
|
Chen, Y.
|
Liang, X.
| +8
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5
Discovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors
enthalten in:
European journal of medicinal chemistry
| 2019
von
Zhan, W.
|
Che, J.
|
Xu, L.
| +7
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6
Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies
enthalten in:
European journal of medicinal chemistry
| 2019
von
Tong, L.
|
Song, P.
|
Jiang, K.
| +10
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7
Design, synthesis and biological evaluation of novel benzothiadiazine derivatives as potent PI3Kδ-selective inhibitors for treating B-cell-mediated malignancies
enthalten in:
European journal of medicinal chemistry
| 2019
von
Ma, X.
|
Wei, J.
|
Wang, C.
| +3
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8
Discovery of a novel series of α-terpineol derivatives as promising anti-asthmatic agents : Their design, synthesis, and biological evaluation
enthalten in:
European journal of medicinal chemistry
| 2018
von
Zhu, W.
|
Liu, X.
|
Wang, Y.
| +2
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9
Discovery of a series of N-(5-(quinolin-6-yl)pyridin-3-yl)benzenesulfonamides as PI3K/mTOR dual inhibitors
enthalten in:
European journal of medicinal chemistry
| 2017
von
Zhang, J.
|
Lv, X.
|
Ma, X.
| +1
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10
Discovery of a series of N-(5-(quinolin-6-yl)pyridin-3-yl)benzenesulfonamides as PI3K/mTOR dual inhibitors
enthalten in:
European journal of medicinal chemistry
| 2017
von
Zhang, J.
|
Lv, X.
|
Ma, X.
| +1
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Zeitschrift: European journal of medicinal chemistry
Medienart
52
Aufsätze
28
E-Artikel
28
E-Ressourcen
24
Gedruckte Aufsätze
Zeitschriftentitel
European journal of medicinal chemistry
Thema
29
Journal Article
14
Research Support, Non-U.S. Gov't
11
Antineoplastic Agents
10
EC 2.7.11.1
9
Protein Kinase Inhibitors
7
Proto-Oncogene Proteins c-akt
4
Enzyme Inhibitors
4
Phosphoinositide-3 Kinase Inhibitors
3
Cancer
3
Molecular docking
2
Akt1 inhibitor
2
Cholinesterase Inhibitors
2
Coumarins
2
EC 2.7.1.137
2
Flavonoids
2
Heterocyclic Compounds, 4 or More Rings
2
Inhibitor
2
Isoquinolines
2
PI3K
2
PK study
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Erscheinungszeitraum
4
2020-
37
2010-2019
11
2000-2009
Erscheinungsjahr(e)
Von:
Bis:
Sprache
33
Englisch
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