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PubPharm (22)
1
Discovery of GSK251 : A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode
enthalten in:
Journal of medicinal chemistry
| 2021
von
Down, K.
|
Amour, A.
|
Anderson, N.
| +23
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2
An Inhaled PI3Kδ Inhibitor Improves Recovery in Acutely Exacerbating COPD Patients : A Randomized Trial
enthalten in:
International journal of chronic obstructive pulmonary disease
| 2021
von
Cahn, A.
|
Hamblin, J.
|
Robertson, J.
| +13
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3
Exploring PI3Kδ Molecular Pathways in Stable COPD and Following an Acute Exacerbation, Two Randomized Controlled Trials
enthalten in:
International journal of chronic obstructive pulmonary disease
| 2021
von
Begg, M.
|
Hamblin, J.
|
Jarvis, E.
| +22
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4
Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma
enthalten in:
Journal of medicinal chemistry
| 2020
von
Smil, D.
|
Wong, J.
|
Williams, E.
| +22
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5
Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target
enthalten in:
Journal of medicinal chemistry
| 2020
von
Henley, Z.
|
Amour, A.
|
Barton, N.
| +22
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6
Translation of Inhaled Drug Optimization Strategies into Clinical Pharmacokinetics and Pharmacodynamics Using GSK2292767A, a Novel Inhaled Phosphoinositide 3-Kinase δ Inhibitor
enthalten in:
The Journal of pharmacology and experimental therapeutics
| 2019
von
Begg, M.
|
Edwards, C.
|
Hamblin, J.
| +16
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7
Discovery of Potent, Efficient, and Selective Inhibitors of Phosphoinositide 3-Kinase δ through a Deconstruction and Regrowth Approach
enthalten in:
Journal of medicinal chemistry
| 2018
von
Barton, N.
|
Convery, M.
|
Cooper, A.
| +8
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8
A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Crossover Study To Investigate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Repeat Doses of Inhaled Nemiralisib in Adults with Persistent, Uncontrolled Asthma
enthalten in:
The Journal of pharmacology and experimental therapeutics
| 2018
von
Khindri, S.
|
Cahn, A.
|
Begg, M.
| +11
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9
Safety, Tolerability, and Pharmacokinetics of Single and Repeat Doses of Nemiralisib Administered via the Ellipta Dry Powder Inhaler to Healthy Subjects
enthalten in:
Clinical therapeutics
| 2018
von
Wilson, R.
|
Jarvis, E.
|
Montembault, M.
| +3
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10
PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner
enthalten in:
Nature communications
| 2018
von
Stark, A.
|
Chandra, A.
|
Chakraborty, K.
| +13
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Thema
17
Journal Article
7
Phosphoinositide-3 Kinase Inhibitors
5
EC 2.7.1.137
5
Research Support, Non-U.S. Gov't
4
Indazoles
4
Sulfonamides
3
Class I Phosphatidylinositol 3-Kinases
3
Klinische Studie
3
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3
Nemiralisib
3
OEP8JJ3OZR
3
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3
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3
nemiralisib
2
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2
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2
Cyclic Nucleotide Phosphodiesterases, Type 4
2
EC 3.1.4.17
2
EC 3.2.1.18
2
Enzyme Inhibitors
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Erscheinungszeitraum
5
2020-
9
2010-2019
8
2000-2009
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18
Englisch
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