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topic_facet:"Pyrimidines"
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/vufind/Search/Results?lookfor=%22Feng%2C+Da%22&type=Person&filter%5B%5D=topic_facet%3A%22Pyrimidines%22
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PubPharm (11)
1
Disubstituted pyrimidine-5-carboxamide derivatives as novel HIV-1 NNRTIs : Crystallographic overlay-based molecular design, synthesis, and biological evaluation
enthalten in:
European journal of medicinal chemistry
| 2023
von
Feng, D.
|
Lin, H.
|
Jiang, L.
| +10
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2
Development of Novel Dihydrofuro[3,4-d]pyrimidine Derivatives as HIV-1 NNRTIs to Overcome the Highly Resistant Mutant Strains F227L/V106A and K103N/Y181C
enthalten in:
Journal of medicinal chemistry
| 2022
von
Kang, D.
|
Sun, Y.
|
Feng, D.
| +10
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3
Design, synthesis, and antiviral evaluation of novel piperidine-substituted arylpyrimidines as HIV-1 NNRTIs by exploring the hydrophobic channel of NNIBP
enthalten in:
Bioorganic chemistry
| 2021
von
Zhang, T.
|
Zhou, Z.
|
Zalloum, W.
| +11
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4
2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs : Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies
enthalten in:
Journal of medicinal chemistry
| 2021
von
Kang, D.
|
Ruiz, F.
|
Sun, Y.
| +11
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5
Design, synthesis, and evaluation of "dual-site"-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase
enthalten in:
European journal of medicinal chemistry
| 2021
von
Feng, D.
|
Zuo, X.
|
Jing, L.
| +10
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6
Targeting dual tolerant regions of binding pocket : Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility
enthalten in:
European journal of medicinal chemistry
| 2020
von
Wang, Z.
|
Kang, D.
|
Feng, D.
| +7
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7
Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties
enthalten in:
Journal of medicinal chemistry
| 2020
von
Kang, D.
|
Feng, D.
|
Sun, Y.
| +6
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8
Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel
enthalten in:
Journal of medicinal chemistry
| 2020
von
Kang, D.
|
Ruiz, F.
|
Feng, D.
| +11
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9
Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors by exploring the structure-activity relationship of solvent-exposed regions I
enthalten in:
Chemical biology & drug design
| 2019
von
Kang, D.
|
Wang, Z.
|
Chen, M.
| +11
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10
Identification of Dihydrofuro[3,4- d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties
enthalten in:
Journal of medicinal chemistry
| 2019
von
Kang, D.
|
Zhang, H.
|
Wang, Z.
| +16
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Thema: Pyrimidines
Medienart
11
Aufsätze
11
E-Artikel
11
E-Ressourcen
Zeitschriftentitel
5
Journal of medicinal chemistry
3
European journal of medicinal chemistry
2
Chemical biology & drug design
1
Bioorganic chemistry
Thema
11
EC 2.7.7.49
11
HIV Reverse Transcriptase
11
Journal Article
Pyrimidines
10
Reverse Transcriptase Inhibitors
8
Anti-HIV Agents
8
Research Support, Non-U.S. Gov't
6
EC 2.7.7.-
6
HIV-1
6
reverse transcriptase, Human immunodeficiency v...
5
NNRTIs
3
Thiophenes
2
0C50HW4FO1
2
DAPY
2
Furans
2
Research Support, N.I.H., Extramural
2
etravirine
2
thiophene[3,2-d]pyrimidine
1
059QF0KO0R
1
284SYP0193
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Erscheinungszeitraum
8
2020-
3
2010-2019
Erscheinungsjahr(e)
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Sprache
11
Englisch
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