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PubPharm (19)
1
Sensitizing Ewing sarcoma to chemo- and radiotherapy by inhibition of the DNA-repair enzymes DNA protein kinase (DNA-PK) and poly-ADP-ribose polymerase (PARP) 1/2
enthalten in:
Oncotarget
| 2017
von
Vormoor, B.
|
Schlosser, Y.
|
Blair, H.
| +4
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2
Combination treatment with rucaparib (Rubraca) and MDM2 inhibitors, Nutlin-3 and RG7388, has synergistic and dose reduction potential in ovarian cancer
enthalten in:
Oncotarget
| 2017
von
Zanjirband, M.
|
Curtin, N.
|
Edmondson, R.
| +1
ErratumIn: Oncotarget. 2024 Feb 22;15:142. - PMID 38386812
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3
PARP inhibitor rucaparib induces changes in NAD levels in cells and liver tissues as assessed by MRS
enthalten in:
NMR in biomedicine
| 2017
von
Almeida, G.
|
Bawn, C.
|
Galler, M.
| +6
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4
Ovarian Cancers Harbor Defects in Nonhomologous End Joining Resulting in Resistance to Rucaparib
enthalten in:
Clinical cancer research : an official journal of the American Association for Cancer Research
| 2017
von
McCormick, A.
|
Donoghue, P.
|
Dixon, M.
| +6
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5
Strategies Employed for the Development of PARP Inhibitors
enthalten in:
Methods in molecular biology (Clifton, N.J.)
| 2017
von
Canan, S.
|
Maegley, K.
|
Curtin, N.
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6
Advanced Ovarian Cancer Displays Functional Intratumor Heterogeneity That Correlates to Ex Vivo Drug Sensitivity
enthalten in:
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
| 2016
von
O'Donnell, R.
|
Kaufmann, A.
|
Woodhouse, L.
| +4
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7
Phase 2 multicentre trial investigating intermittent and continuous dosing schedules of the poly(ADP-ribose) polymerase inhibitor rucaparib in germline BRCA mutation carriers with advanced ovarian and breast cancer
enthalten in:
British journal of cancer
| 2016
von
Drew, Y.
|
Ledermann, J.
|
Hall, G.
| +14
CommentIn: Br J Cancer. 2016 Mar 29;114(7):713-5. - PMID 27022824
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8
Efficacy of PARP Inhibitor Rucaparib in Orthotopic Glioblastoma Xenografts Is Limited by Ineffective Drug Penetration into the Central Nervous System
enthalten in:
Molecular cancer therapeutics
| 2015
von
Parrish, K.
|
Cen, L.
|
Murray, J.
| +11
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9
PARP activity in peripheral blood lymphocytes as a predictive biomarker for PARP inhibition in tumor tissues - A population pharmacokinetic/pharmacodynamic analysis of rucaparib
enthalten in:
Clinical pharmacology in drug development
| 2015
von
Wang, D.
|
Li, C.
|
Sun, W.
| +7
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10
Vasoactivity of rucaparib, a PARP-1 inhibitor, is a complex process that involves myosin light chain kinase, P2 receptors, and PARP itself
enthalten in:
PloS one
| 2015
von
McCrudden, C.
|
O'Rourke, M.
|
Cherry, K.
| +14
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Thema: rucaparib
Medienart
19
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19
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Zeitschriftentitel
5
Clinical cancer research : an official journal ...
2
Molecular cancer therapeutics
2
Oncotarget
2
PloS one
1
British journal of cancer
1
Cancer chemotherapy and pharmacology
1
Clinical pharmacology in drug development
1
International journal of gynecological cancer :...
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Journal of the National Cancer Institute
1
Methods in molecular biology (Clifton, N.J.)
1
NMR in biomedicine
1
Nature medicine
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Thema
19
Journal Article
rucaparib
17
8237F3U7EH
17
Indoles
12
Poly(ADP-ribose) Polymerase Inhibitors
12
Research Support, Non-U.S. Gov't
6
EC 2.4.2.30
5
7GR28W0FJI
5
Dacarbazine
5
Temozolomide
5
YF1K15M17Y
4
Antineoplastic Agents
4
Enzyme Inhibitors
4
Poly(ADP-ribose) Polymerases
3
BRCA1 Protein
3
Poly (ADP-Ribose) Polymerase-1
2
BRCA2 Protein
2
Clinical Trial, Phase I
2
Clinical Trial, Phase II
2
Multicenter Study
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Erscheinungszeitraum
16
2010-2019
3
2000-2009
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19
Englisch
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