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PubPharm (10)
1
Safety, Tolerability, and Pharmacokinetics of a Novel Oral Phosphodiesterase 4 Inhibitor, ME3183 : First-in-Human Phase 1 Study
enthalten in:
Clinical pharmacology in drug development
| 2024
von
Kato, S.
|
Cho, N.
|
Koresawa, T.
| +2
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2
Safety, Tolerability, and Pharmacokinetics of a Novel Oral Phosphodiesterase 4 Inhibitor, ME3183 : First‐in‐Human Phase 1 Study
enthalten in:
Clinical Pharmacology in Drug Development
| 2024
von
Kato, S.
|
Cho, N.
|
Koresawa, T.
| +2
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3
ME3183, a novel phosphodiesterase-4 inhibitor, exhibits potent anti-inflammatory effects and is well tolerated in a non-clinical study
enthalten in:
European journal of pharmacology
| 2024
von
Kubota-Ishida, N.
|
Kaji, C.
|
Matsumoto, S.
| +7
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4
Formation of reactive metabolites of benzbromarone in humanized-liver mice
enthalten in:
Drug metabolism and pharmacokinetics
| 2022
von
Cho, N.
|
Suemizu, H.
|
Kamimura, H.
| +4
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5
Selection of the candidate compound at an early stage of new drug development : retrospective pharmacokinetic and metabolic evaluations of valsartan using common marmosets
enthalten in:
Xenobiotica; the fate of foreign compounds in biological systems
| 2022
von
Matsumoto, S.
|
Uehara, S.
|
Kamimura, H.
| +7
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6
Selection of the candidate compound at an early stage of new drug development: retrospective pharmacokinetic and metabolic evaluations of valsartan using common marmosets
enthalten in:
Xenobiotica
| 2022
von
Matsumoto, S.
|
Uehara, S.
|
Kamimura, H.
| +7
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7
Empirical and theoretical approaches for the prediction of human hepatic clearance using chimeric mice with humanised liver: the use of physiologically based scaling, a novel solution for potential overprediction due to coexisting mouse metabolism
enthalten in:
Xenobiotica
| 2021
von
Matsumoto, S.
|
Kamimura, H.
|
Nishiwaki, M.
| +3
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8
Empirical and theoretical approaches for the prediction of human hepatic clearance using chimeric mice with humanised liver : the use of physiologically based scaling, a novel solution for potential overprediction due to coexisting mouse metabolism
enthalten in:
Xenobiotica; the fate of foreign compounds in biological systems
| 2021
von
Matsumoto, S.
|
Kamimura, H.
|
Nishiwaki, M.
| +3
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9
Association of a reactive intermediate derived from 1',6-dihydroxy metabolite with benzbromarone-induced hepatotoxicity
enthalten in:
Journal of biochemical and molecular toxicology
| 2017
von
Yoshida, M.
|
Cho, N.
|
Akita, H.
| +1
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10
Identification of novel glutathione adducts of benzbromarone in human liver microsomes
enthalten in:
Drug metabolism and pharmacokinetics
| 2017
von
Cho, N.
|
Kobayashi, K.
|
Yoshida, M.
| +3
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1
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Zeitschriftentitel
2
Drug metabolism and pharmacokinetics
2
Xenobiotica
2
Xenobiotica; the fate of foreign compounds in b...
1
Clinical Pharmacology in Drug Development
1
Clinical pharmacology in drug development
1
European journal of pharmacology
1
Journal of biochemical and molecular toxicology
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Thema
7
Journal Article
3
4POG0RL69O
3
Allometry
3
Benzbromarone
3
prediction
2
MIST guidance
2
Pharmaceutical Preparations
2
Phosphodiesterase 4 Inhibitors
2
common marmoset
2
compound optimisation
2
metabolic profile
2
total clearance
2
volume of distribution
1
11128-99-7
1
80M03YXJ7I
1
Angiotensin II
1
Anti-Inflammatory Agents
1
Antihypertensive Agents
1
Atopic dermatitis
1
CYP
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Erscheinungszeitraum
8
2020-
2
2010-2019
Erscheinungsjahr(e)
Von:
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Sprache
9
Englisch
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