Suchergebnisse - "Chappie, Thomas A"

PubPharm (21)

1

First-in-Human Evaluation of 18F-PF-06445974, a PET Radioligand That Preferentially Labels Phosphodiesterase-4B

enthalten in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine | 2022

von Wakabayashi, Y. | Stenkrona, P. | Arakawa, R. | +22

2

Discovery of Small-Molecule CD33 Pre-mRNA Splicing Modulators

enthalten in: ACS medicinal chemistry letters | 2022

von Chappie, T. | Abdelmessih, M. | Ambroise, C. | +9

3

PDE10A Inhibitors-Clinical Failure or Window Into Antipsychotic Drug Action?

enthalten in: Frontiers in neuroscience | 2020

von Menniti, F. | Chappie, T. | Schmidt, C.

4

Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1

enthalten in: Journal of medicinal chemistry | 2018

von Humphrey, J. | Movsesian, M. | Am Ende, C. | +11

5

Correction to Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor

enthalten in: Journal of medicinal chemistry | 2018

von Helal, C. | Arnold, E. | Boyden, T. | +25

ErratumFor: J Med Chem. 2017 Jul 13;60(13):5673-5698. - PMID 28574706

6

Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate

enthalten in: Journal of medicinal chemistry | 2018

von Helal, C. | Arnold, E. | Boyden, T. | +26

7

The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging

enthalten in: Journal of medicinal chemistry | 2017

von Zhang, L. | Chen, L. | Beck, E. | +19

8

Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor

enthalten in: Journal of medicinal chemistry | 2017

von Helal, C. | Arnold, E. | Boyden, T. | +24

ErratumIn: J Med Chem. 2018 Apr 26;61(8):3753. - PMID 29624389

9

Chemoproteomics demonstrates target engagement and exquisite selectivity of the clinical phosphodiesterase 10A inhibitor MP-10 in its native environment

enthalten in: ACS chemical biology | 2014

von Schülke, J. | McAllister, L. | Geoghegan, K. | +6

10

Design and selection parameters to accelerate the discovery of novel central nervous system positron emission tomography (PET) ligands and their application in the development of a novel phosphodiesterase 2A PET ligand

enthalten in: Journal of medicinal chemistry | 2013

von Zhang, L. | Villalobos, A. | Beck, E. | +14