Suchergebnisse - "Botham, Rachel C"

PubPharm (11)

1

Optimizing human α-galactosidase for treatment of Fabry disease

enthalten in: Scientific reports | 2023

von Hallows, W. | Skvorak, K. | Agard, N. | +16

2

Adapting protein sequences for optimized therapeutic efficacy

enthalten in: Current opinion in chemical biology | 2021

von Dellas, N. | Liu, J. | Botham, R. | +1

3

Evaluation of a procaspase-3 activator with hydroxyurea or temozolomide against high-grade meningioma in cell culture and canine cancer patients

enthalten in: Neuro-oncology | 2021

von Tonogai, E. | Huang, S. | Botham, R. | +12

4

Using sulfuramidimidoyl fluorides that undergo sulfur(VI) fluoride exchange for inverse drug discovery

enthalten in: Nature chemistry | 2020

von Brighty, G. | Botham, R. | Li, S. | +8

CommentIn: Nat Rev Drug Discov. 2020 Nov;19(11):754. - PMID 32913211

5

Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients

enthalten in: Oncotarget | 2017

von Joshi, A. | Botham, R. | Schlein, L. | +10

6

Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with Diverse Chemotherapeutics

enthalten in: ACS central science | 2016

von Botham, R. | Roth, H. | Book, A. | +3

7

A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed

enthalten in: Cell reports | 2015

von Palchaudhuri, R. | Lambrecht, M. | Botham, R. | +8

8

Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics

enthalten in: Journal of medicinal chemistry | 2015

von Roth, H. | Botham, R. | Schmid, S. | +3

9

Dual small-molecule targeting of procaspase-3 dramatically enhances zymogen activation and anticancer activity

enthalten in: Journal of the American Chemical Society | 2014

von Botham, R. | Fan, T. | Im, I. | +3

10

Parallel synthesis and biological evaluation of 837 analogues of procaspase-activating compound 1 (PAC-1)

enthalten in: ACS combinatorial science | 2012

von Hsu, D. | Roth, H. | West, D. | +4