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topic_facet:"Pyrimidines"
journalStr:"Journal of medicinal chemistry"
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PubPharm (9)
1
Scaffold decoration at positions 5 and 8 of 1,2,4-triazolo[1,5-c]pyrimidines to explore the antagonist profiling on adenosine receptors : a preliminary structure-activity relationship study
enthalten in:
Journal of medicinal chemistry
| 2014
von
Federico, S.
|
Ciancetta, A.
|
Porta, N.
| +6
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2
Exploring the directionality of 5-substitutions in a new series of 5-alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a strategy to design novel human a(3) adenosine receptor antagonists
enthalten in:
Journal of medicinal chemistry
| 2012
von
Federico, S.
|
Ciancetta, A.
|
Sabbadin, D.
| +6
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3
The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists : new insights into structure-affinity relationship and receptor-antagonist recognition
enthalten in:
Journal of medicinal chemistry
| 2010
von
Cheong, S.
|
Dolzhenko, A.
|
Kachler, S.
| +8
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4
Synthesis and biological studies of a new series of 5-heteroarylcarbamoylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidines as human A3 adenosine receptor antagonists. Influence of the heteroaryl substituent on binding affinity and molecular modeling investigations
enthalten in:
Journal of medicinal chemistry
| 2006
von
Pastorin, G.
|
Da Ros, T.
|
Bolcato, C.
| +7
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5
Combined target-based and ligand-based drug design approach as a tool to define a novel 3D-pharmacophore model of human A3 adenosine receptor antagonists : pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as a key study
enthalten in:
Journal of medicinal chemistry
| 2005
von
Moro, S.
|
Braiuca, P.
|
Deflorian, F.
| +7
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6
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as adenosine receptor antagonists. Influence of the N5 substituent on the affinity at the human A 3 and A 2B adenosine receptor subtypes : a molecular modeling investigation
enthalten in:
Journal of medicinal chemistry
| 2003
von
Pastorin, G.
|
Da Ros, T.
|
Spalluto, G.
| +7
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7
Synthesis, biological properties, and molecular modeling investigation of the first potent, selective, and water-soluble human A(3) adenosine receptor antagonist
enthalten in:
Journal of medicinal chemistry
| 2002
von
Maconi, A.
|
Pastorin, G.
|
Da Ros, T.
| +8
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8
Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists
enthalten in:
Journal of medicinal chemistry
| 2002
von
Baraldi, P.
|
Cacciari, B.
|
Moro, S.
| +7
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9
7-Substituted 5-amino-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as A2A adenosine receptor antagonists : a study on the importance of modifications at the side chain on the activity and solubility
enthalten in:
Journal of medicinal chemistry
| 2002
von
Baraldi, P.
|
Cacciari, B.
|
Romagnoli, R.
| +5
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1
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Thema: Pyrimidines
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Zeitschrift: Journal of medicinal chemistry
Medienart
9
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6
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E-Artikel
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E-Ressourcen
Zeitschriftentitel
Journal of medicinal chemistry
Thema
9
Journal Article
Pyrimidines
8
Research Support, Non-U.S. Gov't
7
Receptor, Adenosine A3
6
Purinergic P1 Receptor Antagonists
6
Triazoles
4
Receptors, Purinergic P1
3
Adenosine A3 Receptor Antagonists
3
Pyrazoles
2
Adenylyl Cyclases
2
Cyclic AMP
2
E0399OZS9N
2
EC 4.6.1.1
2
Furans
2
Receptor, Adenosine A2A
1
1,2,4-triazolo(1,5-c)pyrimidine
1
35920-39-9
1
5-(((4-pyridyl)amino)carbonyl)amino-8-methyl-2-...
1
9009-81-8
1
Acetamides
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Erscheinungszeitraum
3
2010-2019
6
2000-2009
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9
Englisch
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