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PubPharm (23.376)
91
Phase I trial of afatinib in pediatric tumours : Phase I open label, dose escalation trial to determine the MTD, safety, PK and efficacy of afatinib monotherapy in children aged 2 years to <18 years with recurrent/refractory neuroectodermal tumours, rhabdomyosarcoma and/or other solid tumours with known ErbB pathway deregulation regardless of tumour histology - Phase I trial of afatinib in pediatric tumours
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| 2023
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92
A Phase I/IIa Dose Escalation Safety Study of Subretinally Injected StarGen, Administered to Patients with Stargardt's Macular Degeneration. : A Phase I/IIa Dose Escalation Safety Study of Subretinally Injected StarGen, Administered to Patients with Stargardt's Macular Degeneration.
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| 2023
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93
An Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of BIIB067 in Adults With Inherited Amyotrophic Lateral Sclerosis (ALS) : A Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BIIB067 Administered to Adult Subjects with Amyotrophic Lateral Sclerosis and Confirmed Superoxide Dismutase 1 Mutation
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94
The aim of this study is to look at the safety of taking insulin by mouth. Pre-POINT wants to find a dose that causes an immune response. This response will hopefully delay or prevent the start of type 1 diabetes. Children who join this study will get insulin or a placebo (dummy drug) by mouth every day for 3 -18 months. Participants will be closely followed for the development of diabetes autoantibodies and type 1 diabetes for the whole study. : Pre-POINT (Primary Oral INsulin Trial) study A dose finding safety and immune efficacy study for primary mucosal insulin therapy in islet autoantibody negative children at high genetic risk for type 1 diabetes - Pre-POINT
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| 2023
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95
A clinical study to test the safety of CDNF by brain infusion in patients with Parkinson's disease. : A Phase I-II, Randomised, Double-Blind, Placebo Controlled, Safety and Tolerability Study of Intermittent Bilateral Intraputamenal Cerebral Dopamine Neurotrophic Factor (CDNF) Infusions Administered via an Investigational Drug Delivery System to Patients with Idiopathic Parkinson’s Disease (PD) of Moderate Severity.
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| 2023
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96
To investigate the safety and tolerability of AZD9291 when given orally to patients with non small cell lung cancer. These patients will be chosen from those who have already been prescribed an EGFR TKI medicine (such as Iressaor Tarceva). : A Phase I/II, Open-Label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics and Anti-tumour Activity of Ascending Doses of AZD9291 in Patients with Advanced Non Small Cell Lung Cancer who have Progressed Following Prior Therapy with an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Agent (AURA) - AURA
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97
A pilot study evaluating the safety of intravenously administered human amnion epithelial cells for the treatment of hepatic fibrosis : A pilot study evaluating the safety of intravenously administered human amnion epithelial cells for the treatment of hepatic fibrosis
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| 2023
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98
A Phase I/2a study of BMS-986156 given alone and in combination with nivolumab in subjects with advanced solid tumors. : A Phase 1/2a Dose Escalation and Cohort Expansion Study for Safety, Tolerability, and Efficacy of BMS-986156 Administered Alone and in Combination with Nivolumab (BMS-936558, anti-PD-1 Monoclonal Antibody) in Advanced Solid Tumors+ Protocol Amendment 02, Germany-specific, dated 05-Jul-2016+ Protocol Amendment 06, Germany-specific, dated 24-Oct-2016
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99
TREATMENT OF DYSKINESIAS IN PARKINSON’S DISEASE WITH OSU6162 – A PILOT STUDY : TREATMENT OF DYSKINESIAS IN PARKINSON’S DISEASE WITH OSU6162 – A PILOT STUDY
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| 2023
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100
An extension study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of the study drug, RO7234292 (ISIS 443139), in patients who participated in prior investigational studies of RO7234292 : AN OPEN-LABEL EXTENSION STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS AND PHARMACODYNAMICS OF RO7234292 (ISIS 443139) IN HUNTINGTON'S DISEASE PATIENTS WHO PARTICIPATED IN PRIOR INVESTIGATIONAL STUDIES OF RO7234292 (ISIS 443139)
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Thema: Phase: Phase 1
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