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publishDate:"[2010 TO 2019]"
topic_facet:"Phase: Phase 1"
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PubPharm (768)
1
A randomized trial to evaluate the safety, tolerability, and pharmacokinetics of GWP42003-P in conjunction with therapeutic hypothermia in neonates with moderate or severe birth asphyxia : A Randomized, Double-Blind, Placebo-Controlled Single-Ascending Dose Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of GWP42003-P in Conjunction with Hypothermia in Neonates with Moderate or Severe Hypoxic Ischemic Encephalopathy
enthalten in:
WHO International Clinical Trials Registry Platform
| 2019
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2
A Phase I/II Study of Paclitaxel plus Carboplatin and Durvalumab (MEDI4736) with or without Oleclumab (MEDI9447) for Previously Untreated Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer : A Phase I/II Study of Paclitaxel plus Carboplatin and Durvalumab (MEDI4736) with or without Oleclumab (MEDI9447) for Previously Untreated Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer - SYNERGY trial
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WHO International Clinical Trials Registry Platform
| 2019
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3
This is an open-label, fixed-sequence, ascending-dose, first-in-human study to evaluate the safety, tolerability, PK, PD and efficacy of intravenous (IV) ATB200 when co-administered with oral AT2221. : AN OPEN-LABEL, FIXED-SEQUENCE, ASCENDING-DOSE, FIRST-IN-HUMAN STUDY TO ASSESS THE SAFETY, TOLERABILITY, PHARMACOKINETICS, PHARMACODYNAMICS, AND EFFICACY OF INTRAVENOUS INFUSIONS OF ATB200 CO-ADMINISTERED WITH ORAL AT2221 IN ADULT SUBJECTS WITH POMPE DISEASE
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WHO International Clinical Trials Registry Platform
| 2019
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4
A dose escalation trial to assess the safety and tolerability of multiple doses of the CAN04 antibody, in patients with solid malignant tumors. : An open label, dose escalation followed by dose expansion, safety and tolerability trial of CAN04, a fully humanized monoclonal antibody against IL1RAP, in subjects with solid malignant tumors - CANFOUR
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WHO International Clinical Trials Registry Platform
| 2019
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5
A single-dose, open-label, randomised, three-way crossover study to assess the comparative bioavailability of Captopril oral solution 5 mg/mL relative to captopril tablets and to investigate the effect of food on the pharmacokinetics of Captopril oral solution in healthy adult volunteers : A single-dose, open-label, randomised, three-way crossover study to assess the comparative bioavailability of Captopril oral solution 5 mg/mL relative to captopril tablets and to investigate the effect of food on the pharmacokinetics of Captopril oral solution in healthy adult volunteers
enthalten in:
WHO International Clinical Trials Registry Platform
| 2019
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6
A study to test if IMCgp100 in combination with Durvalumab or Tremelimumab or the combination of Durvalumab and Tremelimumab compared to IMCgp100 alone is safe and effective in patients with advanced skin cancer. : A Phase Ib/II Open-label, Multi-center Study of the Safety and Efficacyof IMCgp100 in Combination with Durvalumab (MEDI4736) orTremelimumab or the Combination of Durvalumab and TremelimumabCompared to IMCgp100 Alone in Patients with Advanced Melanoma - IMCgp100-201 Phase Ib/II Study
enthalten in:
WHO International Clinical Trials Registry Platform
| 2019
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7
Efficacy and safety of tisotumab vedotin (HuMax®-TF-ADC) monotherapy in combination in recurrent or Stage IVB cervical cancer : A Phase 1b/2 Open-Label Trial of Tisotumab Vedotin (HuMax®-TF-ADC) Monotherapy and in Combination with Other Agents in Subjects with Recurrent or Stage IVB Cervical Cancer
enthalten in:
WHO International Clinical Trials Registry Platform
| 2019
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8
Afatinib and selumetinib in advanced KRAS mutant positive and PIK3CA wildtype non-small cell lung cancer and colorectal cancer : Phase I/II study with the combination of afatinib and selumetinib in advanced KRAS mutant positive and PIK3CA wildtype non-small cell lung cancer and colorectal cancer
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WHO International Clinical Trials Registry Platform
| 2019
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9
A Phase 1 clinical trial to test the safety, preliminary effects of increasing doses of AZD7648 alone and in combination with other anti-cancer agents in patients with advanced cancers.. : A Phase I/IIa, Open-Label Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of Ascending Doses of AZD7648 Monotherapy or in Combination with either Cytotoxic Chemotherapies or Novel Anti-Cancer Agents in Patients with Advanced Malignancies
enthalten in:
WHO International Clinical Trials Registry Platform
| 2019
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10
A Study of Entrectinib (RXDX-101) in Pediatrics and Young Adults with No Curative First-Line Treatment Option or Recurrent/Refractory Solid Tumors and Primary CNS Tumors : A PHASE 1/2, OPEN-LABEL, DOSE-ESCALATION AND EXPANSION STUDY OF ENTRECTINIB (RXDX-101) IN PEDIATRICS AND YOUNG ADULTS WITH NO CURATIVE FIRST-LINE TREATMENT OPTION OR RECURRENT/REFRACTORY SOLID TUMORS AND PRIMARY CNS TUMORS
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| 2019
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Erscheinungsjahr: 2010-2019
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Medical Condition: Advanced solid tumor;Therape...
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Medical Condition: Cancer MedDRA version: 20.0 ...
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Medical Condition: Advanced Malignant Cutaneous...
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