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publishDate:"[2000 TO 2009]"
topic_facet:"Pyrimidines"
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PubPharm (9)
1
Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction
enthalten in:
Journal of medicinal chemistry
| 2009
von
Allen, J.
|
Bourbeau, M.
|
Wohlhieter, G.
| +18
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2
Molecular target modulation, imaging, and clinical evaluation of gastrointestinal stromal tumor patients treated with sunitinib malate after imatinib failure
enthalten in:
Clinical cancer research : an official journal of the American Association for Cancer Research
| 2009
von
Demetri, G.
|
Heinrich, M.
|
Fletcher, J.
| +12
CommentIn: Clin Cancer Res. 2009 Sep 15;15(18):5603-5. - PMID 19737947
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3
Circulating levels of soluble KIT serve as a biomarker for clinical outcome in gastrointestinal stromal tumor patients receiving sunitinib following imatinib failure
enthalten in:
Clinical cancer research : an official journal of the American Association for Cancer Research
| 2009
von
Deprimo, S.
|
Huang, X.
|
Blackstein, M.
| +7
CommentIn: Clin Cancer Res. 2009 Sep 15;15(18):5603-5. - PMID 19737947
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4
Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor
enthalten in:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
| 2008
von
Heinrich, M.
|
Maki, R.
|
Corless, C.
| +12
CommentIn: J Clin Oncol. 2008 Nov 20;26(33):5322-5. - PMID 18955449
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5
Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase : synthesis, structure-activity relationships, and inhibition of in vivo T cell activation
enthalten in:
Journal of medicinal chemistry
| 2008
von
DiMauro, E.
|
Newcomb, J.
|
Nunes, J.
| +32
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6
N-(3-(phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck : structure, synthesis and SAR
enthalten in:
Bioorganic & medicinal chemistry letters
| 2008
von
Deak, H.
|
Newcomb, J.
|
Nunes, J.
| +12
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7
Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck : development of an expedient and divergent synthetic route and preliminary SAR
enthalten in:
Bioorganic & medicinal chemistry letters
| 2007
von
DiMauro, E.
|
Newcomb, J.
|
Nunes, J.
| +16
ErratumIn: Bioorg Med Chem Lett. 2007 Sep 15;17(18):5280
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8
Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib : a randomised controlled trial
enthalten in:
Lancet (London, England)
| 2006
von
Demetri, G.
|
van Oosterom, A.
|
Garrett, C.
| +14
CommentIn: Nat Clin Pract Oncol. 2007 Jun;4(6):342-3. - PMID 17426720
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9
Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck : synthesis, SAR, and in vivo antiinflammatory activity
enthalten in:
Journal of medicinal chemistry
| 2006
von
Martin, M.
|
Newcomb, J.
|
Nunes, J.
| +42
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1
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Thema: Pyrimidines
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