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journalStr:"Journal of medicinal chemistry"
topic_facet:"Viral Nonstructural Proteins"
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PubPharm (113)
1
Hepatitis C : The Story of a Long Journey through First, Second, and Third Generation NS3/4A Peptidomimetic Inhibitors. What Did We Learn?
enthalten in:
Journal of medicinal chemistry
| 2024
von
Martino, S.
|
Petri, G.
|
De Rosa, M.
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2
Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine
enthalten in:
Journal of medicinal chemistry
| 2023
von
Brewitz, L.
|
Dumjahn, L.
|
Zhao, Y.
| +13
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3
Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors
enthalten in:
Journal of medicinal chemistry
| 2022
von
Gao, S.
|
Song, L.
|
Claff, T.
| +18
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4
Structure-Based Design of a Dual-Targeted Covalent Inhibitor Against Papain-like and Main Proteases of SARS-CoV-2
enthalten in:
Journal of medicinal chemistry
| 2022
von
Yu, W.
|
Zhao, Y.
|
Ye, H.
| +9
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5
Targeting SARS-CoV-2 Main Protease for Treatment of COVID-19 : Covalent Inhibitors Structure-Activity Relationship Insights and Evolution Perspectives
enthalten in:
Journal of medicinal chemistry
| 2022
von
La Monica, G.
|
Bono, A.
|
Lauria, A.
| +1
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6
Diastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main Protease
enthalten in:
Journal of medicinal chemistry
| 2022
von
Cooper, M.
|
Zhang, L.
|
Ibrahim, M.
| +15
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7
Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors : Enzyme Inhibition, Structure-Activity Relationships, Antiviral Activity, and X-ray Structure Determination
enthalten in:
Journal of medicinal chemistry
| 2022
von
Pillaiyar, T.
|
Flury, P.
|
Krüger, N.
| +18
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8
Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors
enthalten in:
Journal of medicinal chemistry
| 2022
von
Huber, S.
|
Braun, N.
|
Schmacke, L.
| +7
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9
Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants
enthalten in:
Journal of medicinal chemistry
| 2021
von
Nageswara Rao, D.
|
Zephyr, J.
|
Henes, M.
| +11
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10
Discovery of Potent and Broad-Spectrum Pyrazolopyridine-Containing Antivirals against Enteroviruses D68, A71, and Coxsackievirus B3 by Targeting the Viral 2C Protein
enthalten in:
Journal of medicinal chemistry
| 2021
von
Hu, Y.
|
Kitamura, N.
|
Musharrafieh, R.
| +1
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Zeitschrift: Journal of medicinal chemistry
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Thema: Viral Nonstructural Proteins
Medienart
113
Aufsätze
92
E-Artikel
92
E-Ressourcen
21
Gedruckte Aufsätze
Zeitschriftentitel
Journal of medicinal chemistry
Thema
113
Antiviral Agents
113
Journal Article
Viral Nonstructural Proteins
64
EC 2.7.7.48
64
NS-5 protein, hepatitis C virus
35
Research Support, Non-U.S. Gov't
25
NS3 protein, hepatitis C virus
24
Enzyme Inhibitors
20
Protease Inhibitors
14
Prodrugs
14
Research Support, N.I.H., Extramural
13
RNA-Dependent RNA Polymerase
12
Serine Proteinase Inhibitors
11
Indoles
10
9DLQ4CIU6V
10
Proline
10
RNA, Viral
10
Sulfonamides
9
EC 3.4.21.-
9
Serine Endopeptidases
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Erscheinungszeitraum
17
2020-
65
2010-2019
29
2000-2009
Erscheinungsjahr(e)
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Sprache
113
Englisch
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