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collection:"CTG"
topic_facet:"Medical Condition: Deficiency of the Cftr-molecule results in accumulation of ceramide in respiratory epithelial cells. Ceramide triggers a pro-inflammatory and -apoptotic status in cystic fibrosis patients. Amitriptyline reduces ceramide levels in the lung tissue, normalises the activity of cytokines and prevents constitutive cell death of epithelial cells. Amitriptyline prevents pulmonary infections of CF-mice with P. aeruginosa. Amitriptyline may result in an improved lung function of cystic fibrosis patients."
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PubPharm (2)
1
Anti-inflammatory pulmonal therapy of CF-patients with Amitriptyline and Placebo : Anti-inflammatory pulmonal therapy of CF-patients with Amitriptyline and Placebo
enthalten in:
WHO International Clinical Trials Registry Platform
| 2022
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2
Anti-inflammatory pulmonal therapy of CF-patients with Amitriptyline and Placebo : Anti-inflammatory pulmonal therapy of CF-patients with Amitriptyline and Placebo
enthalten in:
WHO International Clinical Trials Registry Platform
| 2022
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Thema: Medical Condition: Deficiency of the Cftr-molecule results in accumulation of ceramide in respiratory epithelial cells. Ceramide triggers a pro-inflammatory and -apoptotic status in cystic fibrosis patients. Amitriptyline reduces ceramide levels in the lung tissue, normalises the activity of cytokines and prevents constitutive cell death of epithelial cells. Amitriptyline prevents pulmonary infections of CF-mice with P. aeruginosa. Amitriptyline may result in an improved lung function of cystic fibrosis patients.
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WHO International Clinical Trials Registry Plat...
Thema
2
610
Medical Condition: Deficiency of the Cftr-molec...
2
Phase: Phase 2
2
Recruitment Status: Not yet recruiting
2
Study Type: Interventional
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