Thema
610
8
Recruitment Status: Completed
4
Study Type: Interventional
4
Study Type: Observational
4
Medical Condition: Children with vomiting/ diarrhea constitute about 15% of the pediatric emergency admissions1. Children under the age of five are most infected with viral pathogens as Rota and Noro. The clinical manifestations of viral gastroenteritis include diarrhea, vomiting, fever, anorexia, headache, abdominal cramps and myalgia. The constellation of symptoms varies from day to day and from person to person. Illness usually begins 12 hours to four days after exposure and generally lasts for three to seven days. Usually these diseases are self limiting, but these children are at risk for dehydration. In current practice, these patients are triaged by the nurse then evaluated by the physician for hydration status and diagnosis and, if necessary, fluid replacement therapy is started. Although oral rehydration therapy is the preferred treatment for mild to moderate dehydration, it remains underused. A consensus based guideline2 with assessment for hydration status and recommendations on oral rehydration by experienced emergency care nurses reduced in a before-after trial the number of intravenous rehydrations, unscheduled readmissions and total time spent in hospital3.1 Bouwhuis et al. Ned Tijdschr Geneeskd. 2001;145:1847-51.2 Armon et al. Arch Dis Child. 2001;85:132-42.3 Boyd et al. Emerg Med J. 2005;22:116-7.
2
Medical Condition: Confirmed diagnosis of NASH and Stage 3 or Stage 4 fibrosis based upon the NASH Clinical Research Network (CRN) Histologic Scoring System and a nonalcoholic fatty liver disease (NAFLD) Activity Score (NAS) of 4 or higher, with a score of at least 1 for each of the three components (steatosis, hepatocellular ballooning, and lobular inflammation). MedDRA version: 22.0 Level: PT Classification code 10053219 Term: Non-alcoholic steatohepatitis System Organ Class: 10019805 - Hepatobiliary disorders ;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
2
Medical Condition: Health Condition 1: A00-B99- Certain infectious and parasitic diseasesHealth Condition 2: P969- Condition originating in the perinatal period, unspecifiedHealth Condition 3: Q00-Q99- Congenital malformations, deformations and chromosomal abnormalitiesHealth Condition 4: K639- Disease of intestine, unspecifiedHealth Condition 5: D50-D89- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanismHealth Condition 6: I00-I99- Diseases of the circulatory systemHealth Condition 7: K00-K95- Diseases of the digestive systemHealth Condition 8: N00-N99- Diseases of the genitourinary systemHealth Condition 9: G00-G99- Diseases of the nervous systemHealth Condition 10: J00-J99- Diseases of the respiratory systemHealth Condition 11: G049- Encephalitis, myelitis and encephalomyelitis, unspecifiedHealth Condition 12: E00-E89- Endocrine, nutritional and metabolic diseasesHealth Condition 13: R69- Illness, unspecifiedHealth Condition 14: S00-T88- Injury, poisoning and certain other consequences of external causesHealth Condition 15: K769- Liver disease, unspecifiedHealth Condition 16: G01- Meningitis in bacterial diseases classified elsewhereHealth Condition 17: G98- Other disorders of nervous systemnot elsewhere classifiedHealth Condition 18: G408- Other epilepsy and recurrent seizuresHealth Condition 19: I30-I52- Other forms of heart diseaseHealth Condition 20: J188- Other pneumonia, unspecified organismHealth Condition 21: T36-T50- Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substancesHealth Condition 22: R00-R99- Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classifiedHealth Condition 23: J22- Unspecified acute lower respiratory infectionHealth Condition 24: N19- Unspecified kidney failure
2
Medical Condition: Individuals in a clinically defined at-risk mental state for psychosis # healthy volunteers;F20 - Schizophrenia;F22 - Persistent delusional disorders;F23 - Acute and transient psychotic disorders;F25 - Schizoaffective disorders;F28 - Other nonorganic psychotic disorders;F29 - Unspecified nonorganic psychosis;F31.2 - Bipolar affective disorder, current episode manic with psychotic symptoms;F32.3 - Severe depressive episode with psychotic symptoms;F32 - Depressive episode
2
Phase: Phase 2
2
Recruitment Status: Authorised-recruitment may be ongoing or finished
2
Recruitment Status: Not yet recruiting
2