A Review on the Promising Antibacterial Agents in Bone Cement-from Past to Current Insights
Antibacterial bone cements (ABCs), such as antibiotic-loaded bone cements (ALBCs), have been widely utilized in clinical treatments. Currently, bone cements loaded with vancomycin, gentamicin, tobramycin, or clindamycin are approved by the US Food and Drug Administration. However, traditional ALBCs exhibit drawbacks like burst release and bacterial resistance. Therefore, there is a demand for the development of antibacterial bone cements containing novel agents. In this review, we summarize the latest advancements in ABCs. More importantly, we provide an overview and outlook on novel antibacterial agent-loaded bone cements, including metallic antibacterial agents, pH-switchable antibacterial agents, cationic polymers, N-halamines, non-leaching acrylic monomers, antimicrobial peptides, etc. Offering novel perspectives for designing ABCs and treating bone infections..
Medienart: |
Preprint |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Preprints.org - (2024) vom: 21. Feb. Zur Gesamtaufnahme - year:2024 |
---|
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Lin, Hao [VerfasserIn] |
---|
Links: |
Volltext [kostenfrei] |
---|
doi: |
10.20944/preprints202402.1148.v1 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
preprintsorg042588936 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | preprintsorg042588936 | ||
003 | DE-627 | ||
005 | 20240222120255.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240222s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.20944/preprints202402.1148.v1 |2 doi | |
024 | 7 | |a 10.20944/preprints202402.1148.v1 |2 doi | |
035 | |a (DE-627)preprintsorg042588936 | ||
035 | |a (preprintsorg)10.20944/preprints202402.1148 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Lin, Hao |e verfasserin |4 aut | |
245 | 1 | 0 | |a A Review on the Promising Antibacterial Agents in Bone Cement-from Past to Current Insights |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
520 | |a Antibacterial bone cements (ABCs), such as antibiotic-loaded bone cements (ALBCs), have been widely utilized in clinical treatments. Currently, bone cements loaded with vancomycin, gentamicin, tobramycin, or clindamycin are approved by the US Food and Drug Administration. However, traditional ALBCs exhibit drawbacks like burst release and bacterial resistance. Therefore, there is a demand for the development of antibacterial bone cements containing novel agents. In this review, we summarize the latest advancements in ABCs. More importantly, we provide an overview and outlook on novel antibacterial agent-loaded bone cements, including metallic antibacterial agents, pH-switchable antibacterial agents, cationic polymers, N-halamines, non-leaching acrylic monomers, antimicrobial peptides, etc. Offering novel perspectives for designing ABCs and treating bone infections. | ||
700 | 1 | |a Gao, Zhe |4 aut | |
700 | 1 | |a Asilebieke, Ayakuzi |4 aut | |
700 | 1 | |a Guo, Rui |4 aut | |
700 | 1 | |a Kan, Yu-chen |4 aut | |
700 | 1 | |a Wang, Zhi |4 aut | |
700 | 1 | |a Han, Lu-yang |4 aut | |
700 | 1 | |a Bo, Wen-han |4 aut | |
700 | 1 | |a Han, Long-xu |4 aut | |
700 | 1 | |a Qi, Yan-yu |4 aut | |
700 | 1 | |a Xu, Yang |4 aut | |
700 | 1 | |a He, Fang |4 aut | |
700 | 1 | |a Chu, Jian-jun |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Preprints.org |g (2024) vom: 21. Feb. |
773 | 1 | 8 | |g year:2024 |g day:21 |g month:02 |
856 | 4 | 0 | |u http://dx.doi.org/10.20944/preprints202402.1148.v1 |z kostenfrei |3 Volltext |
912 | |a preprintsorg | ||
951 | |a AR | ||
952 | |j 2024 |b 21 |c 02 |