Associations between gut microbiota and osteoporosis or osteopenia in Chinese Han youth
Abstract Osteoporosis (OP) is a common metabolic bone disease characterized by low bone mass and microstructural deterioration of bone. Changes in the composition and relative abundance of gut microbiota (GM) are related to changes of bone mass and bone microstructure. However, the relationship between GM and bone mineral density (BMD) in Chinese Han youth is complex and still sparse. Therefore, 62 Chinese Han youth were recruited as research volunteers, and their GM and BMD were analyzed separately. Furthermore, according to the evaluation criteria of the World Health Organization (WHO), we divided the BMD levels of volunteers into three groups: osteoporosis (BDL), osteopenia (BDM), normal bone density (BDH). The results showed that the dominant phyla of GM in Chinese Han youth were Bacteroides (50.6%) and Firmicutes (41.6%). Anaerobic bacteria, such as Faecalibacterium and Megamonas, account for the largest proportion in Chinese Han youth, which were mainly Firmicutes. Analysis of the species composition of GM showed that the dominant bacterium in the group with normal bone density (BDH) was Bacteroides and the critical bacteria were Alloprevotella, Enterobacteriaceae, Ruminococcus, Sutterella and Haemophilus. The dominant bacteria in the group classified as osteopenic (BDM) were Prevotella, Megamonas and Prevotella_copri. Faecalibacterium and Bacteroides_Plebeius were the dominant bacteria in the osteoporotic group (BDL) and the critical bacteria were Eubacterium_eligens_group and Lachnospiraceae. There were significant differences in Faecalibacterium (P = 0.018), Bacteroides (P = 0.039), Lachnospiraceae (P = 0.027) and Prevotella (P = 0.045) among the groups. In addition, there were extremely significant differences in Subdoligranulum (P = 0.008), Ruminococcus_bicirculans (P = 0.005), Ruminococcus (P = 0.009) and Coprococcus (P = 0.006) among the groups. In conclusion, our results provide a basic scientific basis for the prevention and treatment of OP..
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Preprint| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
ResearchSquare.com - (2024) vom: 30. März Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lai, Junren [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.21203/rs.3.rs-4163732/v1 |
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| PPN (Katalog-ID): |
XRA043100694 |
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| 520 | |a Abstract Osteoporosis (OP) is a common metabolic bone disease characterized by low bone mass and microstructural deterioration of bone. Changes in the composition and relative abundance of gut microbiota (GM) are related to changes of bone mass and bone microstructure. However, the relationship between GM and bone mineral density (BMD) in Chinese Han youth is complex and still sparse. Therefore, 62 Chinese Han youth were recruited as research volunteers, and their GM and BMD were analyzed separately. Furthermore, according to the evaluation criteria of the World Health Organization (WHO), we divided the BMD levels of volunteers into three groups: osteoporosis (BDL), osteopenia (BDM), normal bone density (BDH). The results showed that the dominant phyla of GM in Chinese Han youth were Bacteroides (50.6%) and Firmicutes (41.6%). Anaerobic bacteria, such as Faecalibacterium and Megamonas, account for the largest proportion in Chinese Han youth, which were mainly Firmicutes. Analysis of the species composition of GM showed that the dominant bacterium in the group with normal bone density (BDH) was Bacteroides and the critical bacteria were Alloprevotella, Enterobacteriaceae, Ruminococcus, Sutterella and Haemophilus. The dominant bacteria in the group classified as osteopenic (BDM) were Prevotella, Megamonas and Prevotella_copri. Faecalibacterium and Bacteroides_Plebeius were the dominant bacteria in the osteoporotic group (BDL) and the critical bacteria were Eubacterium_eligens_group and Lachnospiraceae. There were significant differences in Faecalibacterium (P = 0.018), Bacteroides (P = 0.039), Lachnospiraceae (P = 0.027) and Prevotella (P = 0.045) among the groups. In addition, there were extremely significant differences in Subdoligranulum (P = 0.008), Ruminococcus_bicirculans (P = 0.005), Ruminococcus (P = 0.009) and Coprococcus (P = 0.006) among the groups. In conclusion, our results provide a basic scientific basis for the prevention and treatment of OP. | ||
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| 700 | 1 | |a Liu, Yan |4 aut | |
| 700 | 1 | |a Zhang, Xuelian |4 aut | |
| 700 | 1 | |a Liu, Wenqi |4 aut | |
| 700 | 1 | |a Han, Meng |4 aut | |
| 700 | 1 | |a Zhou, Duoqi |4 aut | |
| 700 | 1 | |a Shi, Shuiqin |4 aut | |
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