Analysis of influencing factors of acute kidney injury after Unilateral nephrectomy Short Title:Analysis of influencing factors of AKI after Unilateral nephrectomy
Abstract Unilateral Nephrectomy is one of the most common treatments for surgical diseases of the kidney but often results in postsurgical acute kidney injury (AKI), although the risk factors have not yet been fully elucidated. It is crucial to identify patients at risk of postsurgical AKI through predictive markers to improve postoperative prognosis. Therefore, in the current study, we aimed to investigate the risk factors for AKI in patients who have received Unilateral Nephrectomy. Methods We retrospectively analysed 528 patients who underwent Unilateral Nephrectomy for different etiologies between January 2013 and December 2018 at the Affiliated Hospital of Qingdao University. We sought to assess the prevalence and severity of AKI in patients with Unilateral Nephrectomy and identify whether age, gender, diabetes, body mass index (BMI), hypertension, preoperative renal function, etiology, performed surgically, anaemia, albumin, coagulation, lactate dehydrogenase, nitrogen (BUN), and uric acid are associated with AKI. Univariate and multivariate logistic regression analyses were used to investigate the predictors of AKI in patients with Unilateral Nephrectomy. Results Overall, 218 of the 528 patients (41.2%) developed AKI during their hospitalisation. Univariate analysis showed that AKI was significantly associated with gender (male, OR = 1.866，P = 0.001), overweight (OR = 2.19, P = 0.0002), and performed surgically (OR = 1.7, P = 0.018), while multivariate logistic regression analysis showed that gender (OR = 1.953, P = 0.001), overweight (OR = 2.176, P = 0.001), and preoperative renal function (OR = 0.507, P = 0.001) were independent factors for AKI. Regression analysis among different etiologies showed significant differences in postoperative AKI. Conclusion After Unilateral nephrectomy, AKI is more likely to occur in overweight male patients withnormal kidney function. AKI occurred more frequently in patients who are kidney donors, but rarely in those with non-function kidneys..
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Preprint| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
ResearchSquare.com - (2024) vom: 15. März Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yan, Yongchao [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.21203/rs.3.rs-4063317/v1 |
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| PPN (Katalog-ID): |
XRA042926386 |
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| 245 | 1 | 0 | |a Analysis of influencing factors of acute kidney injury after Unilateral nephrectomy Short Title:Analysis of influencing factors of AKI after Unilateral nephrectomy |
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| 520 | |a Abstract Unilateral Nephrectomy is one of the most common treatments for surgical diseases of the kidney but often results in postsurgical acute kidney injury (AKI), although the risk factors have not yet been fully elucidated. It is crucial to identify patients at risk of postsurgical AKI through predictive markers to improve postoperative prognosis. Therefore, in the current study, we aimed to investigate the risk factors for AKI in patients who have received Unilateral Nephrectomy. Methods We retrospectively analysed 528 patients who underwent Unilateral Nephrectomy for different etiologies between January 2013 and December 2018 at the Affiliated Hospital of Qingdao University. We sought to assess the prevalence and severity of AKI in patients with Unilateral Nephrectomy and identify whether age, gender, diabetes, body mass index (BMI), hypertension, preoperative renal function, etiology, performed surgically, anaemia, albumin, coagulation, lactate dehydrogenase, nitrogen (BUN), and uric acid are associated with AKI. Univariate and multivariate logistic regression analyses were used to investigate the predictors of AKI in patients with Unilateral Nephrectomy. Results Overall, 218 of the 528 patients (41.2%) developed AKI during their hospitalisation. Univariate analysis showed that AKI was significantly associated with gender (male, OR = 1.866，P = 0.001), overweight (OR = 2.19, P = 0.0002), and performed surgically (OR = 1.7, P = 0.018), while multivariate logistic regression analysis showed that gender (OR = 1.953, P = 0.001), overweight (OR = 2.176, P = 0.001), and preoperative renal function (OR = 0.507, P = 0.001) were independent factors for AKI. Regression analysis among different etiologies showed significant differences in postoperative AKI. Conclusion After Unilateral nephrectomy, AKI is more likely to occur in overweight male patients withnormal kidney function. AKI occurred more frequently in patients who are kidney donors, but rarely in those with non-function kidneys. | ||
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| 700 | 1 | |a Liu, Yunbo |4 aut | |
| 700 | 1 | |a Li, Bin |4 aut | |
| 700 | 1 | |a Zhao, Wenshuo |4 aut | |
| 700 | 1 | |a XU, Shang |4 aut | |
| 700 | 1 | |a Du, Haotian |4 aut | |
| 700 | 1 | |a Li, Yanjiang |4 aut | |
| 700 | 1 | |a Wang, Xinning |4 aut | |
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